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目的:对临床应用倍氯米松鼻喷雾剂(伯克纳)引起鼻中隔穿孔患者进行追踪观察,分析诱发因素,提出预防措施。方法:对1996～1999年应用本品2支以上的178例住院患者,应用鼻窥镜连续追踪观察3～6个月,对鼻中隔病变过程进行临床分析研究。结果:在178例中,鼻中隔粘膜明显缺血12例(6.74％),鼻中隔粘膜变薄6例(3.37％)鼻中隔粘膜缺损3例(1.69％),鼻中隔穿孔5例(2.81％)。结论:严格按照本品说明书操作,并在喷鼻时改变持瓶方法;鼻中隔偏曲矫正术前后慎用或禁用本品;凡连续应用本品者,应每月进行鼻中隔检查,以预防鼻中隔穿孔。
OBJECTIVE: To follow-up observation of patients with nasal septum perforation caused by beclomethasone nasal spray (Berkana) in clinic, and to analyze the inducing factors and propose preventive measures. Methods: A total of 178 inpatients with more than 2 inpatients from 1996 to 1999 were enrolled in this study. The pathological changes of the nasal septum were analyzed by continuous follow-up of 3 to 6 months. Results: In 178 cases, 12 cases (6.74%) had obvious ischemic mucosa of nasal septum, 6 cases (3.37%) had nasal septum mucosa thinning, 3 cases (1.69%) had nasal septal mucosa defect and 5 cases (2.81%) had nasal septal perforation. Conclusion: In strict accordance with the instructions of this product, and change the bottle holding method when nasal spray nasal septum deviation correction before or after caution or disable this product; who continuous application of this product should be nasal septum examination every month to prevent nasal septum perforation.