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本实验采用Ｃ５７ＢＬ／６小鼠皮下接种Ｌｅｗｉｓ肺癌细胞为实验肿瘤模型。当荷瘤小鼠肿瘤局部１０ｍＧｙＸ射线照射前２４ｈ接受７５ｍＧｙ全身照射时，发现对肿瘤生长的抑制作用比单纯局部照射时增强。将７５ｍＧｙ全身照射或假照射的荷瘤小鼠脾细胞与Ｌｅｗｉｓ肺癌细胞混合接种于正常小鼠皮下进行Ｗｉｎｎ试验，观察到照射小鼠脾细胞与癌细胞混合接种的小鼠肿瘤发生率低于假照射小鼠脾细胞与癌细胞混合接种的小鼠，后者肿瘤出现的时间亦较早。这些差别在接种效靶细胞比５０：１的小鼠中更为明显。提示这种抑瘤作用的增强可能是由于低剂量Ｘ射线全身照射后促进荷瘤机体免疫反应所致。＊Ｐ＜０．００１ｖｓ１０Ｇｙｉｒｒａｄ．１６．７％，后者８０％。Ｆｉｇ．２Ｅｆｆｅｃｔｓｏｆｓｐｌｅｎｉｃｃｅｌｌｓｏｆｔｕｍｏｒ─ｂｅａｒ－ｉｎｇｍｉｃｅｆｏｌｌｏｗｉｎｇ７５ｍＧｙＷＢＩｏｎｔｕ－ｍｏｒｉｎｃｉｄｅｎｃｅｉｎａＷｉｎｎａｓｓａｙｔｕｍｏｒｃｅｌｌｏｎｌｙＳｐｌｅｎｏｃｙｔｅｆｒｏｍＴＢＭＳｐｌｅｎｏｃｙｔｅｆｒｏｍＴＢＭＩＴＢＭＴｕｍｏｒ─ｂｅａｒｉｎｇｍｉｃｅＴＢＭＩ：Ｔｍｕｏｒ─ｂｅａｒｉｎｇｍｉｃｅｉｒｒａｄ．＊Ｎｏｔｕ－ｍｏｒｄｅｖｃｌｏｐｉｎｇ?
In this experiment, C57BL/6 mice were inoculated subcutaneously with Lewis lung cancer cells as an experimental tumor model. When the tumor-bearing mice received 75 mGy total body irradiation 24 h before 10 mGy X-ray irradiation, it was found that the inhibition of tumor growth was stronger than that of local irradiation alone. The tumor-bearing mouse spleen cells with 75 mGy total body irradiation or sham irradiation were mixed with Lewis lung cancer cells and inoculated subcutaneously in normal mice for Winn test. It was observed that the incidence of tumors in mice mixed with irradiated spleen cells and cancer cells was lower than that of the mice. Irradiated mouse spleen cells mixed with cancer cells inoculated mice, the latter tumor appeared earlier. These differences are more pronounced in mice immunized with effector cells than in 50:1 mice. It is suggested that the enhancement of this anti-tumor effect may be due to the promotion of tumor-bearing immune response after whole-body irradiation with low-dose X-rays. *P<0.001 vs10 Gyirrad. 16.7%, the latter 80%. Fig. 2Effectsofspleniccellsoftumor─bear-ingmicefollowing75mGyWBIontu-morincidenceinaWinnassaytumorcellonlySplenocytefromTBMSplenocytefromTBMITBMTumor─bearingmiceTBMI:Tmuor─bearingmiceirrad. *Notu-mordevcloping?