新生儿败血症发病急、病情凶险，是新生儿死亡的主要原因之一。由于抗生素的广泛应用和滥用，新生儿败血症的细菌已发生较大变化。现将我院14年来新生儿败血症细菌变异情况简要分析如下。1临床资料1．1一般资料全部病例均以血培养阳性（条件致病菌2次以上），并有一定临床表现 Neonatal sepsis, the incidence of acute and dangerous condition, is one of the main causes of neonatal death. Due to the widespread use and abuse of antibiotics, neonatal sepsis bacteria have undergone major changes. Now 14 years of our hospital neonatal sepsis bacterial variation analysis is as follows. 1 Clinical data 1.1 General information All cases were positive for blood culture (more than two opportunistic pathogens), and a certain clinical manifestations