论文部分内容阅读
目的探讨颅脑外伤患者脑脊液和血液中白细胞介素-6(IL-6)的表达情况。方法选取2015年1—12月辽宁省大连市旅顺口区中医院收治的36例颅脑损伤患者作为研究对象,根据格拉斯哥昏迷评分法(GCS)分为A组(中轻型颅脑损伤)GCS≤8分16例,B组(重型颅脑损伤)GCS>8分20例。采用双抗体夹心酶联免疫吸附法(ELISA)检测所有患者脑脊液和血液中IL-6水平。结果两组患者脑脊液中IL-6水平均明显高于血清组,且B组患者脑脊液中IL-6水平明显高于A组,差异均有统计学意义(均P<0.05);在损伤发生第1天内,两组患者脑脊液和血液中的IL-6水平便开始升高,在72 h达最高浓度,1周左右开始下降,差异均有统计学意义(均P<0.05)。结论在临床上,可以通过动态监测脑脊液中IL-6水平,来了解颅脑损伤的严重程度,以此作为参考来对病情进行判断,以便更加科学、合理的实施治疗,改善患者预后。
Objective To investigate the expression of interleukin-6 (IL-6) in cerebrospinal fluid and blood in patients with craniocerebral trauma. Methods Thirty-six patients with craniocerebral injury admitted in Lhushunkou District Hospital of Traditional Chinese Medicine from January to December 2015 in Dalian were enrolled. According to Glasgow Coma Scale (GCS), patients were divided into group A (mild to moderate craniocerebral injury) GCS≤ 8 points and 16 cases, group B (severe head injury) GCS> 8 points and 20 cases. IL-6 levels in cerebrospinal fluid and blood were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results The levels of IL-6 in cerebrospinal fluid in both groups were significantly higher than those in the serum group, and the levels of IL-6 in cerebrospinal fluid of group B were significantly higher than those in group A (all P <0.05) Within one day, the levels of IL-6 in cerebrospinal fluid and blood began to increase in both groups, reaching the highest concentration at 72 h and then decreasing at about 1 week. The difference was statistically significant (both P <0.05). Conclusions In clinic, we can know the severity of head injury by dynamically monitoring the level of IL-6 in cerebrospinal fluid, which can be used as a reference to judge the condition so that more scientific and reasonable treatment can be implemented and the prognosis of patients can be improved.