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目的:探讨苦参碱在慢性病毒性肝炎抗肝纤维化中的作用。方法:选择140例慢性乙型肝炎(CHB)病人,分苦参碱组及对照组。分别于治疗前后检测肝功能、病毒指标及肝纤维化血清学指标(HA、PCⅢ、Ⅳ-C、LN)。结果:治疗组治疗后肝纤维化指标均明显下降,HA、PCⅢ、Ⅳ-C、LN分别为112.43±39.18ng/ml、113.33±38.77ng/ml、60.13±19.72ng/ml、95.54±39.08ng/ml,与治疗前及对照组治疗后比较,差异显著(均P<0.01)。结论:苦参碱有明显的抗肝纤维化作用。
Objective: To investigate the effect of matrine on liver fibrosis in chronic viral hepatitis. Methods: One hundred and four patients with chronic hepatitis B (CHB) were selected, divided into matrine group and control group. Before and after treatment, liver function, virus index and serological indicators of hepatic fibrosis (HA, PCIII, IV-C, LN) were detected. Results: The liver fibrosis indexes in the treatment group decreased significantly after treatment. HA, PCIII, IV-C, and LN were 112.43±39.18 ng/ml, 113.33±38.77 ng/ml, 60.13±19.72 ng/ml, and 95.54±39.08 ng, respectively. /ml, compared with before treatment and after treatment in the control group, the difference was significant (all P<0.01). Conclusion: Matrine has obvious anti-fibrotic effect.