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目的 :建立心功能不全的动物模型 ,探讨养心康在血流动力学方面的作用及其作用机理。方法 :通过增加腹主动脉压力负荷而建立心功能不全的兔模型 ,以高、低两种不同剂量的养心康治疗 2 0d ,以心宝作为药物对照 ,并设立模型对照和空白对照 ,观察各组模型血流动力学指标及血液中一氧化氮水平在治疗前后的变化。结果 :大剂量养心康能明显降低心衰模型的心率、收缩压、左室舒张末压 (LVEDP) ,心室等容收缩期中室内压上升的最大速率 ( +dp/dtmax)及心室等容舒张期中室内压下降的最大速率 ( -dp/dtmax) ,且呈剂量依赖性 ,与心宝对照组相比具有显著性差异。结论 :养心康能剂量依赖性地改善心衰模型的血流动力学指标 ,延缓心衰的进程 ,其作用可能与一氧化氮的降低有关
Objective: To establish an animal model of cardiac insufficiency and discuss the role and mechanism of Yangxinkang in hemodynamics. METHODS: A rabbit model of cardiac insufficiency was established by increasing the abdominal aortic pressure load. High and low two different doses of Yangxinkang were used for 20 days. The Xinbao was used as a drug control, and model control and blank control were established. The hemodynamic parameters and nitric oxide levels in blood were changed before and after treatment in each group. Results: High-dose Yangxinkangneng can significantly reduce heart rate, systolic blood pressure, left ventricular end-diastolic pressure (LVEDP) in heart failure model, the maximum rate of room pressure increase (+dp/dtmax) during ventricular isovolumic systole and ventricular isovolumic relaxation. The maximum rate of mid-term drop in intraventricular pressure (-dp/dtmax) was dose-dependent and was significantly different from the control group of Xinbao. Conclusion: Yang Xin Kang can dose-dependently improve the hemodynamic parameters of heart failure model and delay the progression of heart failure. Its effect may be related to the reduction of nitric oxide.