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目的 :观察替硝唑洗液的抗厌氧菌活性及对人阴道滴虫的杀灭作用。方法 :采用肉汤试管稀释法测定抗厌氧菌的MIC及MBC ;采用家兔阴道感染人阴道滴虫的模型 ,观察其抗阴道毛滴虫的作用。结果 :替硝唑洗液对 2 0 0株厌氧菌 (除乳杆菌、直杆菌外 )均有较好的抗菌活性 ,其MIC50 均在 2mg/L以下 ,MIC90 略高 ( 1 6mg/L) ,MBC约为MIC的 4～ 1 6倍。替硝唑洗液阴道内直接给药和阴道内冲洗 ,5mg/kg以上对阴道毛滴虫具有明显的杀灭作用 ,2 0mg/kg达痊愈。结论 :替硝唑洗液具有明显的抗厌氧菌活性 ,且对人阴道毛滴虫具有很好的杀灭作用 ,其杀灭滴虫的作用强度优于碧洁洗液
Objective: To observe the anti-anaerobic activity of tinidazole lotion and its killing effect on human vaginal trichomoniasis. Methods: MIC and MBC of anti-anaerobic bacteria were determined by broth tube dilution method. The model of human vaginal trichomonas vaginalis infection in rabbits was used to observe its anti-Trichomonas vaginalis activity. Results: The tinidazole lotion had good antibacterial activity against 200 anaerobic bacteria except Lactobacillus and Strains, the MIC50 was below 2mg / L and the MIC90 was slightly higher (16mg / L) , MBC is about 4 ~ 16 times of MIC. Tinidazole lotion vaginal administration and intravaginal flushing, 5mg / kg above Trichomonas vaginalis obvious killing effect, 20mg / kg up to cure. Conclusion: Tinidazole lotion has obvious anti-anaerobic activity, and has a good killing effect on Trichomonas vaginalis, and the trichomonas killing effect is better than Bi Jie lotion