肝缺血再灌注(IR)过程中,白细胞和细胞因子等不仅参与了肝组织炎症反应,而且极易引起凝血功能的紊乱。组织因子(TF)是一种跨膜糖蛋白,是凝血过程的启动因子,在炎症介质和内毒素等的刺激下,血管内皮细胞和单核细胞及巨噬细胞可表达TF。研究证实,核因子-κB(NF-κB)在肝IR 损伤中发挥着重要作用。现旨在探讨肝I/R损伤中肝组织的炎性浸润与所引起的血液凝血功能失常之间的关系。 During hepatic ischemia-reperfusion (IR), leukocytes and cytokines not only participate in the inflammatory reaction of liver tissue, but also cause the disorder of coagulation function. Tissue factor (TF) is a transmembrane glycoprotein that initiates the process of coagulation and is expressed by vascular endothelial cells and monocytes and macrophages under the stimulation of inflammatory mediators and endotoxins. Studies have shown that nuclear factor-κB (NF-κB) plays an important role in liver IR injury. The purpose of this study was to investigate the relationship between inflammatory infiltration of hepatic tissue and the resulting dysfunction of blood coagulation in liver I / R injury.