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本文用氚标双氢心得舒（３Ｈ－ＤＨＡ）为放射性配基，测定了２０例心衰患儿外周血完整淋巴细胞β－受体密度（Ｂｍａｘ）及血浆去甲肾上腺素（ＮＥ）、肾上腺素（Ｅ）浓度。结果发现心衰病儿血浆ＮＥ、Ｅ浓度明显升高，与心功能呈明显负相关；Ｂｍａｘ则明显降低，与心功能下降程度呈平行关系。美托洛尔治疗后，血浆ＮＥ、Ｅ浓度降低，Ｂｍａｘ升高。治疗前后差异有显著性。为探讨小儿慢性心衰的发病机理及应用β－受体阻滞剂治疗心衰提供重要的理论依据。
In this study, β-adrenergic (NE) and intact lymphocytes (β-adrenoceptors) in peripheral blood of 20 children with heart failure were measured using 3H-DHA as a radioligand. Su (E) concentration. The results showed that plasma concentrations of NE and E were significantly increased in children with heart failure and negatively correlated with cardiac function, while Bmax was significantly decreased with a parallel relationship with decreased cardiac function. Metoprolol treatment, plasma NE, E concentration decreased, Bmax increased. Before and after treatment, the difference was significant. In order to explore the pathogenesis of chronic heart failure in children and the application of β-blockers to treat heart failure provide an important theoretical basis.