本文报告用Ⅲ型胶原蛋白单克隆抗体免疫组化技术,观察胃溃疡周围粘膜胶原蛋白的分布情况。在39例溃疡中,阳性20例,其中6例阳性片中,2例见到胶原蛋白有向粘膜层溃疡边缘移行的现象。本研究提示在胃溃疡中胶原组织的合成是不一样的。今后有可能通过这一技术来区别溃疡的类型,评价溃疡的治疗效果和预后的临床意义,可能为溃疡病的研究开拓一新的领域。 This article reports the use of collagen III monoclonal antibody immunohistochemistry to observe the distribution of collagen around the gastric ulcer. In 39 cases of ulcers, 20 cases were positive, of which 6 cases were positive and 2 cases showed migration of collagen to the edge of mucous layer. This study suggests that the synthesis of collagen in gastric ulcers is not the same. In the future, it is possible to distinguish the types of ulcers by this technique and to evaluate the clinical effects of the therapeutic effects and prognosis of ulcers, which may open up a new field for the study of ulcer disease.