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目的:为了观察益欣康泰对小鼠游泳耐力的影响,以便提供临床用药;方法:选用健康昆明种小鼠75 只,按体重性别随机分成5 组,每组15 只,对照组灌服等体积蒸馏水;阳性对照组给以50g/kg 体重的优质红参醇提液;实验组灌服益欣康泰胶囊高、中、低剂量(15g、10g、5g/kg 体重),分别相当于成人拟服剂量的70 倍、47 倍、25 倍。各组动物于空吸12 小时后灌服给药50 分钟后开始实验。结果:该药可提高小鼠游泳耐力,延长游泳时间(P< 001);结论:提示该药具有增强小鼠体力、提高机体应激能力和抗疲劳作用,本文就其作用机理给读者以初步探讨
Objective: To observe the effect of Yixin Kangtai on swimming endurance of mice in order to provide clinical medication; Method: 75 healthy Kunming mice were randomly divided into 5 groups according to their gender, 15 in each group, and the control group was given an equal volume. Distilled water; the positive control group was given 5 0 g/kg body weight of high-quality red ginseng alcohol extract; the experimental group was fed Yixin Kangtai capsules high, medium, and low doses (15g, 10g, 5g/kg body weight), respectively, equivalent to adults 70 times, 47 times, and 25 times the dose to be taken. Animals in each group started the experiment after oral administration for 50 minutes after aspiration for 12 hours. Results: The drug could increase the swimming endurance of mice and prolong the swimming time (P < 0 01). Conclusion: It is suggested that the drug can increase the physical strength of mice, increase the stress and anti-fatigue effect of the body. Preliminary discussion