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目的 :观察胃炎消对实验性慢性胃炎大鼠的治疗作用。方法 :用酒精和去氧胆酸钠联合造模 90d复制慢性胃炎 (CG)大鼠模型 ;胃炎消按临床用量的 5倍、10倍 ( 12 3 g/kg、2 4 6g/kg)灌胃 ,连续治疗 42d ,观察胃粘膜病理组织学变化。用热板法、醋酸扭体、足跖肿胀和棉球肉芽肿法观察胃炎消的抗炎镇痛作用。结果 :胃炎消可使大鼠胃窦部、窦体交界、胃体、前胃与腺胃交界处胃粘膜的炎症减轻 ,以胃窦部、窦体交界、前胃与腺胃交界处的改善明显 (P <0 .0 5或P <0 .0 1) ;同时胃窦、胃体部粘膜肌层的厚度变薄 ,胃液酸度升至正常。胃炎消还有明显镇痛抗炎作用。结论 :胃炎消对实验性CG大鼠胃粘膜病理组织学变化有明显改善作用和抗炎镇痛作用。
Objective: To observe the therapeutic effect of Weiyanxiao on experimental chronic gastritis rats. METHODS: A rat model of chronic gastritis (CG) was replicated with a combination of alcohol and sodium deoxycholate for 90 days; Weiyanxiao was given intragastric administration five times and 10 times (12 3 g/kg, 244 g/kg) according to clinical dosage. After continuous treatment for 42 days, the histopathological changes of gastric mucosa were observed. The anti-inflammatory and analgesic effects of Weiyanxiao were observed by hot plate method, acetic acid writhing, swollen ankle and cotton ball granuloma. RESULTS: Weiyanxiao can reduce the inflammation of gastric mucosa at the junction of gastric antrum, sinoatrial junction, stomach body, anterior stomach and glandular stomach, and improve the junction of gastric antrum, sinus, and the junction of the anterior stomach and the glandular stomach. Obviously (P <0.05 or P <0.01), the thickness of mucous muscular layer of gastric antrum and stomach body became thin, and acidity of gastric juice rose to normal. Gastritis has obvious analgesic and anti-inflammatory effects. Conclusion: Weiyanxiao has obvious improvement effect on the histopathological changes of gastric mucosa of experimental CG rats and anti-inflammatory and analgesic effects.