论文部分内容阅读
目的探讨端粒重复序列结合因子1(TRF1)和端粒重复序列结合因子2(TRF2)在子宫内膜癌组织中的表达及临床意义。方法利用免疫组织化学SP(SP)法检测46例子宫内膜癌组织和32例正常子宫内膜组织中TRF1和TRF2蛋白的表达,分析临床病理特征与TRF1和TRF2蛋白表达的关系。结果 TRF1蛋白在子宫内膜癌组织中的阳性表达率为32.61%,明显低于正常子宫内膜组织阳性表达率87.50%,差异有统计学意义(P<0.05),TRF2蛋白在子宫内膜癌组织中的阳性表达率为76.09%,明显高于正常子宫内膜组织阳性表达率34.38%,差异有统计学意义(P<0.05);TRF1蛋白低表达和TRF2蛋白高表达与子宫内膜癌病理分级、临床分期、淋巴结是否转移及病理类型等临床病理特征均无相关性(P>0.05);Spearman相关性分析结果显示,TRF1与TRF2在子宫内膜癌组织中的表达呈负相关。结论 TRF1蛋白在子宫内膜癌组织中呈现低表达,TRF2蛋白在子宫内膜癌组织中呈现高表达,推测两者对早期诊断子宫内膜癌具有一定的临床价值。
Objective To investigate the expression and clinical significance of telomeric repeat binding factor 1 (TRF1) and telomeric repeat binding factor 2 (TRF2) in endometrial carcinoma. Methods The expressions of TRF1 and TRF2 in 46 cases of endometrial carcinoma and 32 cases of normal endometrium were detected by immunohistochemical SP (SP) method. The relationship between clinicopathological features and TRF1 and TRF2 protein expression was analyzed. Results The positive expression rate of TRF1 protein in endometrial carcinoma was 32.61%, which was significantly lower than that in normal endometrial tissues (87.50%), the difference was statistically significant (P <0.05). The expression of TRF2 protein in endometrial carcinoma The positive rate of tissue expression was 76.09%, which was significantly higher than that of normal endometrial tissue (34.38%) (P <0.05). The low expression of TRF1 protein and high expression of TRF2 protein correlated with the pathological changes of endometrial carcinoma There was no correlation between the clinicopathological features and clinical stage (P> 0.05). The Spearman correlation analysis showed that the expression of TRF1 and TRF2 in endometrial carcinoma was negatively correlated. Conclusion TRF1 protein is low expressed in endometrial carcinoma tissues and TRF2 protein is highly expressed in endometrial carcinoma tissues. It is presumed that TRF1 protein has some clinical value in the early diagnosis of endometrial carcinoma.