近年来,随着对端粒酶的研究深入,应用靶向端粒酶的方法治疗肿瘤成为热点,并有较多的新进展,如:应用端粒酶hTERT的免疫抗原性进行肿瘤的免疫治疗;端粒酶启动子驱动的肿瘤基因治疗等。本文简要介绍端粒酶与肿瘤的密切关系,并就针对端粒酶靶向治疗肿瘤的研究进展进行综述。1端粒酶 In recent years, with the further research on telomerase, the application of telomerase targeting tumor has become a hot spot, and there are more new progress, such as: the use of telomerase hTERT immunogenic antigenic tumor immunotherapy ; Telomerase promoter driven tumor gene therapy. This article briefly describes the close relationship between telomerase and tumor, and reviews the research progress of targeting telomerase targeted therapy of tumor. 1 telomerase