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目的:研究钙增敏剂MCI-154对内毒素血症家兔心功能的影响.方法:内毒素血症家兔静脉注射MCI-154 1.0 mg·kg~(-1),然后再输入50 mL·kg~(-1)生理盐水(NS)+MCI-154 0.1 mg·kg~(-1)液体.监测心功能指标.结果:单纯给予50 mL·kg~(-1) NS治疗,对内毒素血症家兔心功能无明显改善作用.MCI-154+NS治疗后,左室收缩压(LVSP)、左室等容收缩压(IP)、心肌收缩性能(MC)、心肌收缩向量环面积(Lo)明显增加,显著高于单纯NS治疗组.MCI-154治疗后,心率(HR)无明显增加,左室舒张末压(LVEDP)明显降低.结论:钙增敏剂MCI-154对家兔内毒素血症心功能障碍具有良好的治疗效果.
Objective: To study the effect of calcium sensitizer MCI-154 on cardiac function in rabbits with endotoxemia.Methods: Rabbits with endotoxemia were intravenously injected with 1.0 mg · kg -1 MCI-154 and then with 50 mL · Kg -1 NS and MCI-154 0.1 mg · kg -1 were used to monitor the cardiac function.Results: After treatment with 50 mL · kg -1 NS alone, After the treatment of MCI-154 + NS, left ventricular systolic pressure (LVSP), left ventricular isometric systolic pressure (IP), myocardial contractility (MC), myocardial systolic vector annulus area (Lo) was significantly increased, significantly higher than the NS group.MCI-154 treatment, no significant increase in heart rate (HR), left ventricular end-diastolic pressure (LVEDP) decreased significantly.Conclusion: MCI- Rabbit endotoxemia cardiac dysfunction with good therapeutic effect.