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Sam68是一种细胞内信号转导及RNA激活蛋白,通过自身的多个功能性模体与RNA,Src激酶家族及其他多种细胞内信号分子相作用。它作为细胞信号转导过程中的衔接蛋白参与细胞周期的调控,与细胞增殖和凋亡密切相关。其表达异常可导致细胞的恶性转化。
Sam68 is an intracellular signaling and RNA-activating protein that interacts with RNA, the Src kinase family, and many other intracellular signaling molecules through its own multiple functional motifs. As an adapter protein in cell signal transduction, it participates in the regulation of cell cycle and is closely related to cell proliferation and apoptosis. Its abnormal expression can lead to malignant transformation of cells.