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目的:比较小儿影像学检查中三种常用镇静催眠剂的有效性和安全性。方法:选取2014年10月至2015年6月在我院行影像学检查时应用镇静催眠剂的小儿436例,根据所用药物分为水合氯醛组206例、地西泮组145例、苯巴比妥组85例,对三组患儿镇静催眠效果及不良反应进行观察和评价。结果:水合氯醛组、地西泮组、苯巴比妥组的有效率分别为89.81%(185/206)、97.93%(142/145)、94.12%(80/85),不良反应发生率分别为11.65%(24/206)、3.45%(5/145)、3.53%(3/85),三组有效率及不良反应比较差异有统计学意义(P<0.05)。结论:小儿影像学检查应用的水合氯醛、地西泮、苯巴比妥这三种常用镇静催眠剂中,地西泮的有效性和安全性最高。
OBJECTIVE: To compare the efficacy and safety of three commonly used sedative and hypnotic agents in pediatric imaging studies. Methods: From October 2014 to June 2015, 436 children with sedative and hypnotizing agents undergoing imaging examination in our hospital were divided into 206 cases of chloral hydrate group, 145 cases of diazepam group, 85 patients in the bitumen group, the sedation and hypnosis effects and adverse reactions in the three groups were observed and evaluated. Results: The effective rates of chloral hydrate group, diazepam group and phenobarbital group were 89.81% (185/206), 97.93% (142/145), 94.12% (80/85), respectively. The incidence of adverse reactions Respectively, which were 11.65% (24/206), 3.45% (5/145) and 3.53% (3/85), respectively. There was significant difference between the three groups in the efficacy and adverse reactions (P <0.05). CONCLUSION: Diazepam is the most effective and safe diazepam for diazepam and phenobarbital in pediatric imaging studies.