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对~(147)Pm从妊娠晚期及泌乳BALD/c 小鼠向子代的转移及其在母体内主要沉积器官的分布进行了研究和对比。在妊娠17天及分娩后1天,经尾静脉给雌性BALB/c小鼠注射~(147)Pm硝酸溶液。分别于注射后1,4,9,14和21天活杀动物,取母鼠肝脏、右侧股骨、子宫和子鼠、胎盘及胎膜,制成生物样品进行分析测量。结果显示:泌乳和妊娠动物子鼠中~(147)Pm含量随时间延长而增加,且泌乳动物子鼠体内~(147)Pm含量在注射后1和4天分别比妊娠动物子鼠高20多倍,妊娠晚期注射~(147)Pm硝酸溶液1和4天后,胎盘、胎膜~(147)Pm含量均明显高于子 鼠体内~(147)Pm含量。妊娠和泌乳组母鼠肝脏中~(147)Pm生物半排期比对照组动物为高,骨骼中~(147)Pm也明显高于对照动物。
Metastasis of ~ (147) Pm from offspring and lactating BALD / c mice to offspring and their distribution in the maternal sediment were studied and compared. Female BALB / c mice were injected with ~ (147) Pm nitric acid solution via the tail vein at 17 days gestation and 1 day after childbirth. The animals were sacrificed on the 1st, 4th, 9th, 14th and 21th day after injection, respectively. The liver, right femur, uterus and fetus, placenta and fetal membranes were taken for analysis and measurement. The results showed that the content of ~ (147) Pm in lactating and gestational pregnant rats increased with time, and the content of ~ (147) Pm in lactating animals was higher than that in pregnant rats by 1 and 4 days after injection The levels of ~ (147) Pm in placenta and fetal membranes ~ (147) Pm were significantly higher in ~ (147) Pm nitric acid solution injected into the third trimester of gestation than in the second trimester of pregnancy. The half-life of ~ (147) Pm in the liver of pregnant and lactating maternal rats was higher than that of the control animals, and the ~ (147) Pm in the bones was also significantly higher than that of the control animals.