Schistosomiasis is a parasitic disease. They propagate in the Yangtze River valley of Chi-na. The spread of the disease is solely through a middle-agent named oncomelania, so the spread ofschistosomiasis by oncomelania can be controlled by properly designing water intakes which preventoncomelania from entering the farming land or residential areas. In this paper, a successful design pro-cess is reported and a new oncomelania-free intake device is demonstrated in the laboratory. The de-sign of the new intake is based on a sound research program in which an extensive experimental stud-ies have been carried out to gain knowledge of oncomelania eco-hydraulic behaviors and a detailed flowfield information is obtained through CFD simulation.