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采用部分均衡顺序随机对照开放试验方法对洛美沙星片刊进行临床评价．共治疗各种感染２９２例，其中呼吸系统感染６１例与环丙沙星６０例对照．泌尿多统感染４１例与诺氟沙星４０例对照。结果显示洛美沙星片剂治疗总有效率为９３．５％，对呼吸系统感染洛美沙星片剂治疗痊愈率为６０％，有效率为８Ｓ．２％，对照药环丙沙星痊愈卓５６．７％，有效率为８１．７％，两组比较无显著性差异（Ｐ＞０．０５）。对泌尿系统感染洛美沙星片剂治疗痊愈率为８０．５％，有效率为９２．７％，诺氟沙星治疗痊愈率力６５．０％，有效率为８２．６％，两组比较无显著性差异（Ｐ＞０．０５）。本试验细菌培养阳性率为９２．６％，洛美沙星细菌清除率为９１．％，体外抗菌活性表明洛美沙星对大多数革兰氏阴性菌和阳性菌均只有良好的抗菌作用。洛美沙星不良反应为３．７％，程度轻微，主要为消化道反应．
The clinical trial of lomefloxacin was carried out with partial equilibrium sequence randomized controlled open trial. A total of 292 cases of various infections were treated, of which 61 cases of respiratory infection and ciprofloxacin 60 cases of control. 41 cases of multiple urinary tract infection and norfloxacin 40 cases of control. The results showed that the total effective rate of lomefloxacin tablets was 93.5%, and the recovery rate of lomefloxacin tablets was 60% and the effective rate was 8S. 2%, control drug ciprofloxacin recovered Zhuo 56.7%, the effective rate was 81.7%, no significant difference between the two groups (P> 0.05). Urinary tract infection lomefloxacin tablets cure rate was 80.5%, the effective rate was 92.7%, norfloxacin cure rate of 65.0%, the effective rate was 82.6%, two groups compared No significant difference (P> 0.05). The test positive rate of bacterial culture was 92.6%, lomefloxacin bacterial clearance rate of 91. %, In vitro antibacterial activity shows that lomefloxacin most Gram-negative bacteria and positive bacteria are only good antibacterial effect. Lomefloxacin adverse reaction was 3.7%, a slight degree, mainly for gastrointestinal reactions.