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目的 研究系统性红斑狼疮 (SLE)患者外周淋巴细胞 (PBL)增殖反应及其产生白细胞介素 2 (IL 2 )的情况。方法 淋巴细胞增殖法及IL 2检测法。结果 SLE患者PBL的增殖反应明显高于正常人 ,但SLE患者PBL产生IL 2的能力明显低于正常人。结论 SLE患者PBL增殖反应提高和其产生IL 2能力降低可能与T细胞两亚群TH1 /TH2 的失衡有关。
Objective To investigate the proliferative response of peripheral lymphocytes (PBLs) and the production of interleukin 2 (IL 2) in patients with systemic lupus erythematosus (SLE). Methods Lymphocyte proliferation and IL-2 assay. Results The proliferative response of PBL in patients with SLE was significantly higher than that in normal people, but the ability of PBL to produce IL 2 in patients with SLE was significantly lower than that in normal people. Conclusion The increase of PBL proliferation and the decrease of IL 2 production in patients with SLE may be related to the imbalance of TH1 / TH2 in T lymphocyte subsets.