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目的探讨格列美脲联合盐酸二甲双胍治疗2型糖尿病的临床疗效及安全性。方法将我院收治的2型糖尿病患者90例,随机分为对照组与治疗组,每组45例,对照组给予格列美脲治疗,治疗组给予格列美脲联合盐酸二甲双胍治疗,1周为1个疗程,两组均连续治疗2个疗程后,检测空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)变化,统计两组治疗过程中不良反应发生率,评价临床疗效。结果治疗后,治疗组的FBG、PBG以及HbA1c明显低于对照组(P<0.05);治疗组的显效率和总有效率明显高于对照组(P<0.05);两组不良反应发生率比较无显著性差异(P>0.05)。结论格列美脲联合盐酸二甲双胍治疗2型糖尿病的临床疗效确切,不良反应小,值得推广。
Objective To investigate the clinical efficacy and safety of glimepiride combined with metformin hydrochloride in the treatment of type 2 diabetes mellitus. Methods Totally 90 type 2 diabetic patients admitted to our hospital were randomly divided into control group and treatment group, with 45 cases in each group. The control group was treated with glimepiride. The treatment group was treated with glimepiride and metformin hydrochloride for 1 week As a course of treatment. After two courses of continuous treatment for both groups, fasting blood glucose (FBG), postprandial 2h blood glucose (PBG), HbA1c changes were measured. The incidence of adverse reactions in the two groups was calculated, Efficacy. Results After treatment, FBG, PBG and HbA1c in the treatment group were significantly lower than those in the control group (P <0.05). The effective rate and total effective rate in the treatment group were significantly higher than those in the control group (P <0.05). The incidence of adverse reactions in the two groups No significant difference (P> 0.05). Conclusion The combination of glimepiride and metformin hydrochloride in the treatment of type 2 diabetes has definite curative effect and small adverse reactions and is worth popularizing.