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目的:探讨鼻咽癌患者治疗前后血清血管内皮生长因子(VEGF)水平的变化及其临床意义。方法:ELISA法对75例鼻咽癌患者在治疗前、治疗结束后1个月和治疗后出现局部复发或远处转移者,同步检测40例慢性鼻咽炎患者及30名正常人血清VEGF水平。结果:鼻咽癌组Ⅲ～Ⅳ期患者治疗前血清VEGF水平均显著高于Ⅰ～Ⅱ期患者(P<0.01);与治疗前比较,Ⅰ～Ⅱ期、Ⅲ～Ⅳ期患者治疗后血清VEGF水平均显著下降(P<0.01);治疗后,Ⅰ～Ⅱ期与Ⅲ～Ⅳ期患者血清VEGF水平比较,差异无统计学意义;与慢性鼻咽组及正常对照组比较,鼻咽癌复发组患者治疗前、后的血清VEGF水平明显升高(P<0.01);与治疗前组比较,鼻咽癌患者治疗后的血清VEGF水平明显下降(P<0.01),而复发组治疗后明显上升(P<0.01)。结论:血清VEGF水平可作为鼻咽癌患者治疗前后病情监测一个新的检测指标。
Objective: To investigate the changes of serum vascular endothelial growth factor (VEGF) level in patients with nasopharyngeal carcinoma before and after treatment and its clinical significance. Methods: Serum levels of VEGF in 75 patients with nasopharyngeal carcinoma (NPC) before treatment, one month after treatment and local recurrence or distant metastasis were detected by ELISA. Results: The levels of serum VEGF in stage Ⅲ ~ Ⅳ nasopharyngeal carcinoma patients before treatment were significantly higher than those in stage Ⅰ ~ Ⅱ patients (P <0.01). Compared with those before treatment, the levels of serum VEGF (P <0.01). After treatment, there was no significant difference in serum VEGF levels between stage Ⅰ ~ Ⅱ and stage Ⅲ ~ Ⅳ. Compared with chronic nasopharyngeal group and normal control group, the recurrence of nasopharyngeal carcinoma group Serum VEGF levels in patients before and after treatment were significantly increased (P <0.01). Compared with the pre-treatment group, the serum VEGF levels in patients with nasopharyngeal carcinoma were significantly decreased (P <0.01), while the recurrence group was significantly increased after treatment P <0.01). Conclusion: Serum VEGF levels can be used as a new detection index for the monitoring of patients with nasopharyngeal carcinoma before and after treatment.