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阿泊拉可乐宁(apraclonidine)是可乐宁(clonidine)的衍生物,一种α_2-肾上腺素能促效剂。早已有报告,可乐宁可使眼压明显下降,但也可使血压明显下降,妨碍了它在眼科临床上的应用。阿泊拉可乐宁可使眼压明显下降而不影响血压。它使平均眼压下降25%,持续12小时。已被用于临床,有效地预防激光小梁成形术和虹膜切除术后的眼压升高。阿泊拉可乐宁主要通过使房水生成减少而降低眼压。它的副作用有结膜苍白,轻度散瞳和眼睑退缩。
Apraclonidine is a derivative of clonidine, an alpha 2 -adrenergic agonist. It has been reported that clonidine can significantly reduce intraocular pressure, but also can significantly lower blood pressure, hinder its clinical application in ophthalmology. Apkalacline can significantly reduce intraocular pressure without affecting blood pressure. It reduces the average IOP by 25% for 12 hours. Has been used clinically to effectively prevent elevated intraocular pressure after laser trabeculoplasty and iridectomy. Abercrombie mainly reduces the intraocular pressure by reducing the production of aqueous humor. Its side effects are pale conjunctiva, mild mydriasis and eyelid withdrawal.