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目的:探讨孕激素受体(PR)和碱性成纤维细胞生长因子(b-FGF)在放置左炔诺孕酮宫内缓释系统(LNG-IUS)(商品名:曼月乐)避孕并异常子宫出血患者子宫内膜表达情况及其作用机制。方法:放置曼月乐后阴道不规则出血患者60例,根据阴道不规则流血时间分为A组(放置曼月乐1月时仍阴道出血患者子宫内膜)30例,B组(放置曼月乐2月时仍阴道出血患者子宫内膜)30例,对照组(A+B组放置曼月乐时患者子宫内膜)60例。采取免疫组化法测定各组子宫内膜中PR、b-FGF的表达水平。结果:A、B组与对照组相比,PR表达明显上升,且出血时间越长PR表达越明显,差异有统计学意义(P<0.05);A、B组与对照组相比,b-FGF表达明显减弱,且出血时间越长b-FGF表达越低,差异有统计学意义(P<0.05)。结论:曼月乐导致避孕妇女子宫内膜中PR、bFGF的异常表达与其异常子宫出血密切相关。
Objective: To investigate the effect of progestin receptor (PR) and basic fibroblast growth factor (b-FGF) on the contraceptive of levonorgestrel-releasing intrauterine system (LNG-IUS) Abnormal uterine bleeding in patients with endometrial expression and its mechanism of action. Methods: Sixty patients with vaginal irregular bleeding after Mirena injection were divided into group A (30 cases of endometrium with vaginal bleeding in January) and group B 30 cases of vaginal bleeding in patients with endometrial bleeding in February and 60 cases of control group (patients with endometrium in M + M group in group A + B). Immunohistochemistry was used to detect the expression of PR and b-FGF in the endometrium of each group. Results: Compared with the control group, the expression of PR significantly increased in group A and group B, and the longer the bleeding time was, the more obvious the expression of PR was, the difference was statistically significant (P <0.05). Compared with control group, the expression of b- FGF expression was significantly weakened, and the longer bleeding time b-FGF expression, the difference was statistically significant (P <0.05). Conclusion: The abnormal expression of PR and bFGF in endometrium caused by Mirena is closely related to abnormal uterine bleeding.