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研究用12只β受体阻断的麻醉杂种犬,冠脉左旋支及左股动脉用腹主动脉血经恒压泵恒流灌注。交感神经电刺激(左星状神经节及腹腔交感链)与不同浓度去甲肾上腺素(NE)一次动脉注射引起动脉收缩反应。冠脉对大、小剂量的NE反应都不被α1受体阻断剂减弱,提示NE引起的冠脉反应主要是通过突触后α2受体,股动脉对小剂量NE的反应不被α1受体阻断减弱,但对大剂量NE的反应却因α1受体阻断而明显受抑制,提示股动脉对小剂量NE的收缩反应主要是通过α2受体,α1受体阻断剂还能明显阻断冠脉与股动脉对交感神经刺激的部分反应,但只有在α1与α2受体同时被阻断后,才能完全消除交感神经刺激引起的动脉收缩反应,提示突触后α2受体也受神经支配。
To study the use of 12 β-blocker anesthetized mongrel dogs, left anterior descending coronary artery and left aorta blood flow by constant-pressure pump perfusion. Sympathetic nerve stimulation (left stellate ganglion and peritoneal sympathetic chain) and different concentrations of norepinephrine (NE) an arterial injection caused by arterial contractions. Coronary artery on the large and small doses of NE were not obstructed by α1 receptor antagonist, suggesting that NE-induced coronary response is mainly through the postsynaptic α2 receptor, femoral artery response to small doses of NE is not α1 by However, the response to high dose of NE was significantly inhibited by the blockade of α1 receptor, suggesting that the contractile response of femoral artery to low dose NE was mainly through α2 receptor and α1 receptor blocker Blocking the coronary and femoral arteries on the sympathetic stimulation part of the response, but only in the α1 and α2 receptor blocked at the same time, can completely eliminate the sympathetic nerve stimulation-induced arterial contractions, suggesting that post-synaptic α2 receptor also Innervation.