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花生四烯酸(AA)的生物活性衍生物包括前列腺素(PGs)、血栓素(TXs)、羟廿碳四烯酸(HETEs)和白三烯(LTs)。在对免疫性和非免疫性刺激物的应答中,从白细胞和上皮细胞膜中的AA通过脂氧合酶的作用生成LTs。脂氧合酶活性存在于嗜中性白细胞、嗜酸性白细胞、巨噬细胞、肥大细胞及血小板中。近来发现,人角朊细胞受刺激后可释放少量白三烯B_4(LTB_4)。生物效应对吞噬性白细胞(嗜中性白细胞、嗜酸性白细胞及单核细胞)的作用:除引起白细胞粘附于内皮细胞上外,LTB_4是目前已知的最强的趋化性和化学动力性物质。HETEs和
Bioactive derivatives of arachidonic acid (AA) include prostaglandins (PGs), thromboxanes (TXs), hydroxyeicosatetraenoic acids (HETEs) and leukotrienes (LTs). In response to both immune and non-immune stimuli, LTs are produced by the action of lipoxygenases from AA in leukocytes and epithelial cell membranes. Lipoxygenase activity is present in neutrophils, eosinophils, macrophages, mast cells and platelets. Recently found that human keratinocytes can release a small amount of leukotriene B_4 (LTB_4). Biological effects on phagocytic leukocytes (neutrophils, eosinophils and monocytes): In addition to causing leukocytes to adhere to endothelial cells, LTB_4 is the strongest chemotactic and chemokinetic known to date substance. HETEs and