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目的 :探讨血栓调节蛋白 ( TM)在多器官功能障碍综合征 ( MODS)中的表达及其意义。方法 :应用免疫组织化学技术 ,对 MODS死亡标本的心、肺、肾组织 TM进行检测。结果 :MODS组心、肺、肾组织 TM表达多为阳性及强阳性 ,对照组多为弱阳性及阳性 ,两者间比较差异均有显著意义 ( P均 <0 .0 1)。结论 :TM增加导致的凝血平衡失调可能是 MODS的主要发病机制之一。
Objective: To investigate the expression of thrombomodulin (TM) in multiple organ dysfunction syndrome (MODS) and its significance. Methods: Immunohistochemistry was used to detect the TM, lung and kidney tissue of MODS death specimens. Results: The expressions of TM in heart, lung and kidney tissue of MODS group were mostly positive and strongly positive, while the control group were mostly weakly positive and positive. There was significant difference between the two groups (all P <0.01). Conclusion: The imbalance of coagulation balance caused by TM increase may be one of the main pathogenesis of MODS.