论文部分内容阅读
目的:利用临床资料和病例资料的回顾性分析,阐明慢性丙型肝炎患者合并脂肪肝的比例和临床病理学特点,为了解慢性丙型病毒性肝炎的脂肪变病理特征,探索新型治疗技术和方法奠定基础.方法:对于经过肝脏活检的159例慢性丙型肝炎患者的临床和病理学特点进行回顾性分析,阐明慢性丙型肝炎合并肝脏脂肪变的比例和临床、病理学特点.根据病理改变的类型和程度,分析慢性丙型肝炎患者合并脂肪肝的流行率、临床与病理学特点.计量资料应用SAS统计学软件进行分析.结果:159例慢性丙型肝炎患者中有131例患者合并肝脏脂肪变,占82.39%(131/159).对其中112例患者进行了病理改变的程度分析,轻度、中度和重度分别为29.46%(33/112)、60.71%(68/112)和9.82%(11/112);对其中131例患者进行病理类型分类,小泡型、大泡型和混合型分别为47.33%(62/131)、3.82%(5/131)和48.85%(64/131).对于慢性丙型肝炎患者合并脂肪肝进行多因素相关回归分析,结果表明慢性丙型肝炎合并脂肪肝的病理类型、病变程度与是否合并其他肝炎病毒感染、HCVRNA是否阳性、是否有输血史及年龄等因素无关,但与性别有关.男性与女性患者相比,合并肝脏脂肪变的慢性丙型肝炎女性患者以小泡型为主.而男性患者以混合型为主;女性患者以轻度和中度为主,没有重度患者,而男性患者则以中度和重度为主,总的来说,男性患者病理改变较女性患者为重.性别之间的差异有显著的统计学意义.结论:82.39%慢性丙型肝炎患者合并肝脏脂肪变,肝脏脂肪变的病理分型和病理改变程度与性别有关,女性患者脂肪肝病变较轻,男性较重.
OBJECTIVE: To investigate retrospective analysis of clinical data and case data to clarify the proportion of patients with chronic hepatitis C with fatty liver and clinicopathological features, in order to understand the pathological features of steatohepatitis C fatty steatohepatitis, to explore new treatment techniques and methods Methods: The clinical and pathological features of 159 patients with chronic hepatitis C after liver biopsy were retrospectively analyzed to elucidate the proportion and clinical and pathological features of chronic hepatitis C with hepatic steatosis.According to the pathological changes Type and degree of fatty liver in patients with chronic hepatitis C. The prevalence, clinical and pathological features of fatty liver in patients with chronic hepatitis C were analyzed.Measurement data were analyzed by SAS statistical software.Results: Among the 159 patients with chronic hepatitis C, 131 patients had liver fat , Accounting for 82.39% (131/159) .Among the 112 patients, the degree of pathological changes were mild, moderate, and severe respectively 29.46% (33/112), 60.71% (68/112) and 9.82 % (11/112). The pathological types of 131 patients were classified as 47.33% (62/131), 3.82% (5/131) and 48.85% (64 / 131). For chronic type C. Multiple regression analysis of fatty liver with inflammation in patients with chronic hepatitis C showed that the pathological type of chronic hepatitis C with fatty liver and the degree of the disease were not related to whether other hepatitis viruses were infected, whether HCVRNA was positive, history of blood transfusion and age or not Gender-related men and women compared with patients with liver steatohepatitis in patients with chronic hepatitis C vesicle-based, while male patients with mixed-based; female patients with mild and moderate-based, no Severe patients, while male patients are mainly moderate and severe, in general, the male patients with pathological changes than the female patients.Statistical difference was statistically significant.Conclusion: 82.39% of chronic hepatitis C Patients with liver steatosis, liver steatosis pathological types and pathological changes related to gender, female patients with fatty liver lesions lighter, heavier men.