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目的:研究厚朴酚与和厚朴酚对大鼠回肠短路电流的影响。方法:应用体外Ussing chamber系统评价50μmol/L、100μmol/L、200μmol/L厚朴酚或和厚朴酚对回肠短路电流的作用。结果:厚朴酚与和厚朴酚均能明显抑制大鼠回肠的短路电流,且短路电流呈浓度依赖性降低,同时,其对短路电流的抑制效应显著高于钙通道阻滞剂维拉帕米;不同浓度的厚朴酚与和厚朴酚预处理可以显著降低10μmol/l乙酰胆碱激活的短路电流的增加。结论:厚朴酚与和厚朴酚可抑制大鼠回肠的短路电流,其作用机制可能是作为钙离子拮抗剂,通过调控肠道钙离子通道功能来抑制钙离子或其他离子的转运。
Objective: To study the effects of magnolol and honokiol on short-circuit current in rat ileum. Methods: The effects of 50 μmol / L, 100 μmol / L, 200 μmol / L honokiol and honokiol on ileal short-circuit current were evaluated by in vitro Ussing chamber system. Results: Both magnolol and honokiol could significantly inhibit the short-circuit current in rat ileum, and the short-circuit current decreased in a concentration-dependent manner. Meanwhile, the inhibitory effect on short-circuit current was significantly higher than that of calcium channel blocker Verapam Rice; different concentrations of honokiol and honokiol pretreatment can significantly reduce the increase of 10μmol / l acetylcholine activation short-circuit current. CONCLUSION: Magnolol and honokiol can inhibit the short-circuit current in rat ileum. The mechanism may be as a calcium antagonist, which can inhibit the transport of calcium ions or other ions through the regulation of intestinal calcium channel function.