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目的:探讨较高水平血β-hCG(2 000~8 000 IU/L)输卵管妊娠的保守治疗方案。方法:将106例输卵管妊娠要求保守治疗的患者随机分为复方组和对照组,每组53例。复方组口服复方米非司酮片+肌内注射氨甲蝶呤(MTX)+口服本院协定处方宫外孕方+口服大黄蛰虫胶囊;对照组除不服用复方米非司酮片外,其余治疗同复方组。结果:临床总有效率复方组为96.2%,对照组为75.5%,组间比较差异有统计学意义(P<0.05);复方组45例1个疗程内治愈,对照组23例1个疗程内治愈,组间差异有显著统计学意义(P<0.01),阴道流血时间、平均住院时间、血β-hCG转阴时间和盆腔包块消失时间组间比较均有统计学差异(P<0.05)。结论:复方米非司酮协同MTX及中药治疗输卵管妊娠,能明显提高有较高水平血β-hCG(2 000~8 000 IU/L)输卵管妊娠的治愈率。
Objective: To investigate the conservative treatment of tubal pregnancy with higher levels of β-hCG (2 000-8 000 IU / L). Methods: 106 cases of tubal pregnancy requiring conservative treatment of patients were randomly divided into compound and control groups, 53 cases in each group. The compound prescription mifepristone tablets intramuscular injection of methotrexate (MTX) + oral administration of this protocol prescription ectopic pregnancy prescription + oral rhubarb insects capsule; the control group except not taking the compound mifepristone tablets, the rest of the treatment Same group. Results: The total clinical effective rate was 96.2% in the compound group and 75.5% in the control group, with significant difference between the two groups (P <0.05); 45 cases in the compound group were cured in one course and 23 cases in the control group in one course There was significant difference between the two groups (P <0.01), vaginal bleeding time, average hospitalization time, blood β-hCG negative conversion time and pelvic mass disappearance time (P <0.05) . Conclusion: Compound mifepristone combined with MTX and Chinese herbs in the treatment of tubal pregnancy can significantly improve the cure rate of tubal pregnancy with higher levels of β-hCG (2 000-8 000 IU / L).