【摘 要】
：
A series of pyrrolo[1,2-a]pyrazinone compounds(5a-9f) were synthesized,and their cytotoxic activity against SKOV-3,A549.HeLa cells in vitro were evaluated by th
【机 构】
：
Key Laboratory of Structure-Based Drug Design and Discovery,Ministry of Education,Shenyang Pharmaceu
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
A series of pyrrolo[1,2-a]pyrazinone compounds(5a-9f) were synthesized,and their cytotoxic activity against SKOV-3,A549.HeLa cells in vitro were evaluated by the MTT method.Some of the compounds showed potential antitumor activity against three tumor cell lines.Among them,compounds 9c and 9d showed the most potent cytotoxic activity.The preliminary mechanism of action was discussed.
A series of pyrrolo [1,2-a] pyrazinone compounds (5a-9f) were synthesized, and their cytotoxic activity against SKOV-3, A549. HeLa cells in vitro were evaluated by the MTT method. activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.
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