急性肾衰竭是临床上常见的一种综合征,尽管用人工肾治疗,其死亡率依然很高,一般内科病例为25%,创伤病例为63%。死亡率所以还很高与其病理生理发病机制尚未完全解决有关。研究急性肾衰竭的发病机制,除对临床实例之外,通过动物实验也是必不可少的有效途径。最近三十多年来,人们对急性肾衰竭这个领域的认识已经有了很大提高,在这方面,建立实验性急性肾衰竭模型,显然起了很大推动作用。本实验用二氯化汞(HgCl_2)造 Acute renal failure is a common clinical syndrome, although the treatment of artificial kidney, the mortality rate is still high, the general medical cases were 25%, trauma cases were 63%. Therefore, the mortality rate is still very high and its pathogenesis has not yet been fully resolved. Research on the pathogenesis of acute renal failure, in addition to clinical examples, through animal experiments is also an effective and effective way. In recent thirty years, people’s understanding of acute renal failure has been greatly improved. In this respect, it is clear that the establishment of an experimental model of acute renal failure has played a significant role in promoting this. This experiment with mercury dichloride (HgCl_2) made