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本研究中有12名健康志愿者(9名女子和3名男子)接受安慰剂对照的随机交叉双盲试验。经4小时禁食后,在第1天中午这些对象每人给予三小包车前草(一种扩容积药,每包3.6g)或三小包安慰剂,溶于100ml水中口服;一分钟后进食标准餐(445卡,600ml,碳水化合物40g,脂肪23g,蛋白质21g)。胃排空的超声图估值是通过服药前即刻和此后6小时内每小时测定一次脊柱前垂直位胃窦直径来取得的。同时,进食前和进食后6小时内每小时要求受试者在一个100mm垂直分度表的线上打“×”以表示饥饿程度,从完全不饿=0至最饿=100。餐后饱足感每小时也按此法记录6小时,“空胃”=0和“饱足”=100。经7天间歇后,按同样方法交叉试验。测试期间受试者维持静息。
Twelve healthy volunteers (9 women and 3 men) in this study were randomized, placebo-controlled, cross-blind, double-blind. After 4 hours of fasting, on the first day at noon, each of these subjects received three tablets of Psyllium (3.6 grams per pack) or three small packs of placebo dissolved orally in 100 ml of water; one minute after eating Standard meal (445 calories, 600 ml, carbohydrates 40 g, fat 23 g, protein 21 g). An estimate of gastric emptying was obtained by measuring the diameter of the anterior vertebral vertical antrum immediately before taking medication and hourly after 6 hours thereafter. At the same time, subjects were asked to dial “x” on a line of 100 mm vertical graduation meters hourly before eating and 6 hours after eating to indicate the degree of hunger, ranging from 0% to 100%. Postprandial satiety also recorded by the law six hours per hour, “empty stomach” = 0 and “full” = 100. After seven days intermittent, the same method of cross-test. Subjects remained at rest during the test.