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目的探讨采用配伍方法进行药物流产后出血时间长的原因。方法一组２２例，服米非司酮（Ｒｕ４８６）及米索前列醇药物流产，二组２０例采用吸宫术终止妊娠。分别于妊囊排出或吸宫后第５、１４、２４天抽肘静脉血测血ｈＣＧ、Ｐ、Ｅ２、ＦＳＨ、ＬＨ及ＰＲＬ，同时记录出血时间。结果发现Ｒｕ４８６组血中ｈＣＧ下降缓慢，流产后１４、２４天的ｈＣＧ明显高于吸宫术组。虽然两组各时间Ｅ２值无显著性差异，但是Ｒｕ４８６组各时间的Ｅ２值均低于吸宫组。两组各时间的Ｐ、ＬＨ、ＦＳＨ、ＰＲＬ值均无显著性差异（Ｐ＞００５）。结论Ｒｕ４８６合并米索终止早孕引起出血多、时间长，与子宫蜕膜剥脱慢、ｈＣＧ下降缓慢、雌激素不足、子宫内膜修复慢有关。
Objective To explore the reasons for using a combination of methods for medical treatment of bleeding after a long time. Methods A group of 22 patients, taking mifepristone (Ru486) and misoprostol drug abortion, the second group of 20 patients with endoscopic pregnancy termination. Bleeding blood samples were collected from the elbow venous blood on the 5th, 14th and 24th day after the pregnant or spontaneous discharge, respectively. The bleeding time was also recorded. The results showed that the blood hCG Ru486 group decreased slowly, 14 and 24 days after abortion hCG was significantly higher than the suction group. Although there was no significant difference in the E2 values between the two groups at each time point, E2 values in the Ru486 group at each time were lower than those in the control group. There were no significant differences in P, LH, FSH and PRL between the two groups (P> 005). Conclusion Ru486 combined with misoprostol termination of early pregnancy caused more bleeding, a long time, with the decidual exfoliation of the uterus slow, hCG decreased slowly, lack of estrogen, endometrial repair slow.