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目的 :探讨p53蛋白表达在食管癌中的临床意义。方法 :用鼠抗人p53单克隆抗体 ,以SP免疫组化法检测p53蛋白。结果 :p53蛋白阳性表达率为 56 3% ,其表达与肿瘤大小、TNM分期、有无淋巴结转移无关 (P >0 0 5) ,与肿瘤分化程度有关 (P <0 0 1)。p53蛋白阳性组与阴性组比较 ,其术后生存率有显著差异 (P <0 0 1)。结论 :食管癌组织中p53蛋白表达与肿瘤大小、TNM分期及有无淋巴结转移无关 ,与肿瘤分化程度密切相关 ,并可用于判断预后
Objective: To investigate the clinical significance of p53 protein expression in esophageal cancer. Methods: The mouse anti-human p53 monoclonal antibody was used to detect the p53 protein by SP immunohistochemistry. Results: The positive expression rate of p53 protein was 56.3%. The expression of p53 protein was not related to tumor size, TNM stage and lymph node metastasis (P> 0.05), which was correlated with the degree of tumor differentiation (P <0.01). The postoperative survival rate of p53 protein positive group was significantly different from that of negative group (P <0.01). Conclusion: The expression of p53 protein in esophageal carcinoma is not related with tumor size, TNM stage and lymph node metastasis, and is closely related to the degree of tumor differentiation, and can be used to judge the prognosis