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目的 探讨乙型肝炎病毒不同复制程度对肝纤维化进程的作用。方法 173例患者分为 6组 :慢性肝炎轻、中、重度 3组 ,肝硬化Child -PughA级、B级、C级 3组 ,采用放射免疫法测定慢性乙型肝炎、肝硬化患者血清白细胞介素 - 6 (IL -6 )、白细胞介素 - 8(IL - 8)、Ⅲ型前胶原 (PⅢP)、Ⅳ型胶原 (c -Ⅳ )含量 ,并同时测定HBV -DVA ,按阳性、阴性不同进行分组比较。结果 血清IL - 6、IL - 8、PⅢP、c -Ⅳ含量 ,当HBV -DNA(+)时与HBV -DNA(- )时相比较 ,除在肝炎轻度组、肝硬化C级组无显著差异外 (P >0 0 5 ) ,其余 4组皆有统计学意义 ,以重度组、A级组为显著 (P <0 0 1)。结论 乙型肝炎病毒活跃复制可加重肝脏损害 ,促进肝星状细胞 (HSC)的活化及活化持续 ,从而在肝纤维化的起始、持续发展过程中具有重要作用
Objective To investigate the effect of hepatitis B virus (HBV) replication on the progression of hepatic fibrosis. Methods 173 patients were divided into 6 groups: light, moderate and severe chronic hepatitis group 3, Child-Pugh class of cirrhosis, B class, C class 3 group, using radioimmunoassay in patients with chronic hepatitis B, cirrhosis serum leukocyte The levels of IL - 6, IL - 8, P Ⅲ P and C Ⅳ in serum of patients with HBV - Group comparison. Results The levels of IL - 6, IL - 8, PⅢP and c - Ⅳ in serum were significantly lower than those in HBV - DNA (-) when HBV - DNA (P> 0.05). The other four groups were statistically significant, with severe group and A group as significant (P <0.01). Conclusion Active replication of hepatitis B virus can aggravate liver damage and promote the activation and activation of hepatic stellate cells (HSC), which play an important role in the initiation and continuous development of hepatic fibrosis