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目的探讨血清同型半胱氨酸(homocysteine,Hcy)在原发性肝癌(Primary hepatic carcinoma,PHC)中的表达及其意义。方法分别测定113例原发性肝癌、80例肝硬化患者和50例正常体检者血清中的Hcy的水平,并进行相关的统计学分析。结果原发性肝癌和肝硬化组血清Hcy水平明显升高(P﹤0.01～0.05),且随着Child分级的升高而递增。结论同型半胱氨酸(Hcy)是反映原发性肝癌肝功能损害的敏感指标,对PHC早期诊断、疗效判断、预后监测有重要的临床意义。
Objective To investigate the expression and significance of serum homocysteine (Hcy) in primary hepatic carcinoma (PHC). Methods The serum levels of Hcy in 113 cases of primary hepatocellular carcinoma, 80 cases of cirrhosis patients and 50 cases of normal subjects were measured respectively, and related statistics were analyzed. Results Serum Hcy levels in primary hepatocellular carcinoma and cirrhosis group were significantly increased (P <0.01 ~ 0.05), and increased with Child grading. Conclusions Hcy is a sensitive index to reflect the damage of hepatic function of primary liver cancer. It has important clinical significance for the early diagnosis, curative effect judgment and prognosis monitoring of PHC.