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受试者为39～64岁的14例变异型心绞痛男性患者,即静息时发生心绞痛伴心前导联ST段抬高。冷加压试验(CPT)前停用硝酸酯和硝苯啶。舌下含服硝酸甘油(缓解心绞痛)例外。无一例使用β阻滞剂或洋地黄。A组7例CPT前12～16h静脉注射单剂乙酰水杨酸的赖氨酸盐3.6mg/kg(相当于阿司匹林2mg/kg),B组7例则否。空腹口服安定10mg后,受试者将手置于冰水内3min。 CPT前A组主动脉血和心大静脉血血栓素B_2(TxB_2,TxA_2的稳定代谢产物)浓度均低于B组(45±16对109±56pg/ml,p<0.02;47±19对176±88pg/ml,p<0.005)。CPT第3min A组主动脉血和心大静脉血TxB_2浓度均低于B组(48±30对160±92
The subjects were 14 patients with variant angina at 39-64 years of age who developed angina pectoris with anterior ST segment elevation at rest. Nitrate and nifedipine are discontinued before cold pressurisation (CPT). Sublingual nitroglycerin (relieve angina) exception. No one used beta blockers or digitalis. A group of 7 patients before 12-12h CPT intravenous injection of a single dose of lysine salt of acetylsalicylic acid 3.6mg / kg (equivalent to aspirin 2mg / kg), B group 7 cases no. After oral administration of 10mg diazepam, the subjects placed their hands in ice water for 3 minutes. The concentrations of thromboxane B 2 (the stable metabolites of TxB 2 and TxA 2) in aorta and ventricular vein before CPT in group A were lower than those in group B (45 ± 16 vs 109 ± 56 pg / ml, p <0.02; 47 ± 19 vs 176 ± 88 pg / ml, p <0.005). The concentration of TxB_2 in aorta and venous blood of group A at 3 min after CPT was lower than that of group B (48 ± 30 vs 160 ± 92