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目的研究血管内皮生长因子(vascular endothelial growth factor,VEGF)和染色体空间重组因子-1(remodeling and spacing factor 1,Rsf-1)在宫颈癌组织中的表达情况,进一步分析其与发病年龄、临床分期、组织学类型、病理学分级和淋巴结转移的相关性,探讨两者联合应用在宫颈癌病理诊断中的意义。方法本研究选择经手术治疗、有明确病理诊断的56例宫颈癌蜡块标本作为观察组。同时选取56例正常宫颈组织作为对照组,采用免疫组织化学方法检测VEGF和Rsf-1的表达水平。结果观察组中VEGF阳性表达率明显高于对照组(P<0.05);观察组Rsf-1阳性表达率同样明显高于对照组(P<0.05)。观察组VEGF和Rsf-1因子的阳性表达在不同年龄分段、组织学类型及FIGO分期的宫颈癌组织中差异无统计学意义,但两者在病理学分级和淋巴结转移方面的比较差异具有统计学意义(P<0.05)。结论 VEGF以及Rsf-1在宫颈癌组织中呈现高表达,与宫颈癌发生、发展、预后具有相关性,有望作为宫颈癌临床病理的辅助诊断和对宫颈癌患者病情综合判断的实验室及临床预后指标。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and remodeling-spacing factor 1 (Rsf-1) in cervical cancer and to further analyze the relationship between the expression of VEGF and age, clinical stage , Histological type, pathological grade and lymph node metastasis, to explore the significance of the combination of the two in the pathological diagnosis of cervical cancer. Methods In this study, 56 cases of cervical cancer with definite pathological diagnosis were selected as the observation group. At the same time, 56 cases of normal cervical tissue were selected as the control group, and the expression of VEGF and Rsf-1 were detected by immunohistochemistry. Results The positive rate of VEGF in the observation group was significantly higher than that in the control group (P <0.05). The positive rate of Rsf-1 in the observation group was also significantly higher than that in the control group (P <0.05). The positive expression of VEGF and Rsf-1 in the observation group had no statistical significance in different age groups, histological types and FIGO staging of cervical cancer, but the differences in pathological grade and lymph node metastasis between the two groups were statistically significant Significance (P <0.05). Conclusions The expression of VEGF and Rsf-1 in cervical cancer tissues is highly expressed, which is correlated with the occurrence, development and prognosis of cervical cancer. It is expected to serve as a laboratory and clinical prognostic factor for the diagnosis of cervical cancer and the prognosis of patients with cervical cancer index.