肾动脉射频消融术(radiofrequency ablation of the renal arteries,RF-ABL)已被证明能降低已接受降压药治疗但疗效不佳的高血压患者的血压。然而,现在仍然有很多疑问关于RF-ABL怎样做到不依赖药物治疗而影响血压,和是否有必要完全去肾神经来最大限度地降低血压。为了明确这些问题,本研究检测自发性高血压大鼠(spontaneously hypertensive rats,SHR)行近端肾动脉RF-ABL后对心血管、交感 Radiofrequency ablation of the renal arteries (RF-ABL) has been shown to reduce blood pressure in hypertensive patients who have undergone antihypertensive treatment but have poor response. However, there are still many questions about how RF-ABL can affect blood pressure independent of drug treatment and whether it is necessary to completely remove the renal nerves to minimize blood pressure. In order to clarify these problems, this study was designed to detect cardiovascular and sympathetic responses after spontaneous hypertensive rats (SHR) with RF-ABL proximal to the renal artery.