在细胞免疫缺陷特别是CD4~+T细胞数量或功能缺陷的人群中,新生隐球菌感染是致病和致死的重要原因。尽管T细胞反应在宿主抗新生隐球菌的免疫反应中起着至关重要的作用,引起这一保护性反应的抗原还远未研究清楚,但目前认为其中至少有部分抗原属于甘露糖肽素家族。最近,研究人员用新生隐球菌粗提抗原免疫小鼠,将这种小鼠的脾 Cryptococcus neoformans infection is an important cause of morbidity and mortality in the population of cellular immunodeficiency, especially CD4 ~ + T cells or dysfunction. Although T cell responses play a crucial role in host immune response against Cryptococcus neoformans, the antigen responsible for this protective response is far from clear, but at least some of the antigens presently are believed to belong to the mannoside family . Recently, the researchers immunized mice with Cryptococcus neoformans crude extract, the spleen of this mouse