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目的探讨白血病染色体微卫星不稳定性（ＭＳＩ）及杂合性丢失（ＬＯＨ）。方法用白血病易位断裂点区域附近的多个微卫星位点检测３０例不同类型白血病基因的不稳定性及杂合性丢失。结果２１例白血病存在ＭＳＩ或者ＬＯＨ。其中１５例急性白血病中１１例示１个以上位点有ＭＳＩ；６例慢性粒细胞性白血病中４例患者在３个以上位点有ＭＳＩ；１５例急性白血病中２例有ＬＯＨ，比其他白血病发生率高。结论白血病和骨髓增生异常综合征均存在较高的基因不稳定性，但这些基因变化与不同类型的白血病的染色体易位断裂点没有特殊联系
Objective To investigate the chromosomal microsatellite instability (MSI) and loss of heterozygosity (LOH) in leukemia. Methods The detection of the instability and loss of heterozygosity of 30 different leukemia genes by microsatellite loci near the breakpoint of leukemia translocation. Results There were MSI or LOH in 21 cases of leukemia. Of the 15 acute leukemias, 11 showed MSI in more than one locus; 4 of the 6 patients with chronic myeloid leukemia had MSI at more than 3 loci; 2 of 15 acute leukemias had LOH, which occurred more than other leukemias High rate. Conclusions Both leukemia and myelodysplastic syndromes have high genetic instability, but these gene changes have no special relationship with different types of leukemia chromosomal translocation breakpoints