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目的了解成人双生子血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)的水平及其遗传度。方法选择青岛市双生子库中316对18到60岁的健康成人双生子,用自动生化分析仪检测其空腹血清TC、HDL-C、LDL-C、TG的浓度。鉴定卵性后,用Mx软件拟合遗传模型,调整性别、年龄后,计算血脂相关指标的遗传度。结果双生子空腹血清TC、HDL-C、LDL-C、TG水平的均值分别为(4.52±1.08)、(1.46±0.39)、(2.58±0.79)、(1.11±0.77)mmol/L。Mx软件拟合结构方程模型结果显示,TC、HDL-C和LDL-C三项指标的最适模型为AE模型,其遗传度依次为53%、62%和57%。TG的最适模型为CE模型,遗传度为0。结论遗传因素和环境因素对TC、HDL-C和LDL-C的浓度都有重要影响,而TG主要受到环境因素的影响。
Objective To investigate the levels of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) in adult twins and their heritability. Methods Two hundred and sixty-six pairs of healthy twins from 18 to 60 years old were selected from twins in Qingdao. The levels of fasting serum TC, HDL-C, LDL-C and TG were detected by automatic biochemical analyzer. After the identification of egg, Mx software fitting genetic model, adjust the gender, age, calculate the blood fat-related indicators of heritability. Results The fasting serum TC, HDL-C, LDL-C and TG levels of twins were (4.52 ± 1.08), (1.46 ± 0.39), (2.58 ± 0.79) and (1.11 ± 0.77) mmol / L, respectively. Mx software fitting structural equation model results show that TC, HDL-C and LDL-C three indicators of the most appropriate model for the AE model, the heritability were 53%, 62% and 57%. The optimal model of TG is the CE model with a heritability of 0. Conclusion The genetic factors and environmental factors have an important impact on the concentrations of TC, HDL-C and LDL-C, while TG is mainly affected by environmental factors.