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MGK是一种药物吸收促进剂,它是由1-碘苯腈辛酸甘油酯55～57%(w/v),1,3-二碘苯腈辛酸甘油酯20%,1,2-二碘苯腈辛酸甘油酯9%,三碘苯腈辛酸甘油酯3%,碘苯腈辛酸3%和甘油8%所组成的混合物。许多实验证明MGK对头孢美唑和头孢唑啉等抗生素的肠道吸收有显著的促进作用。本文以头孢唑啉钠(极性化合物)作为药物模型,分别制成(1)含有上述各种单一组分的头孢唑啉钠溶液(15mg/ml),(2)含有MGK的头孢唑啉钠溶液(15mg/ml)和(3)不含促进剂的头孢唑啉钠溶液(15mg/ml)。分别取上述溶液200μl,恒速输入鼠颈静脉或直肠给药,给药后定时由颈动脉取血100μl,
MGK is a drug absorption enhancer consisting of 55 to 57% (w / v) 1-Iodobenzene caprylic glyceride, 20% glycerol caprylate 1,3-diiodoanilide, 1,2-diiodine 9% glycyrrhizin caprylate, 3% triiodochiprin caprylate, 3% iodobenzene nitrile and 8% glycerol. Many experiments show that MGK has a significant promotion effect on intestinal absorption of antibiotics such as cefmetazole and cefazolin. In this paper, cefazolin sodium (polar compound) was used as the drug model to make (1) a solution of cefazolin sodium (15 mg / ml) containing various single components as described above, (2) cefazolin sodium Solution (15 mg / ml) and (3) cefazolin sodium solution without accelerator (15 mg / ml). Respectively, take the above solution 200μl, constant speed into the jugular vein or rectum, after administration of blood from the carotid artery 100μl,