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目的 探讨阿霉素磁性蛋白微球 (ADM MAMs)靶向给药后动物体内靶区组织中的药代动力学状况。方法 将 10 0只Wastar大白鼠分为A组 (消化道给药靶向组 ) ,B组 (消化道给药非靶向组 ) ,C组 (尾静脉给药靶向组 ) ,D组 (尾静脉给药非靶向组 ) ,每组 2 4只动物 ,应用荧光分光光度法检测并比较每组大白鼠胃壁、肝脏组织及门静脉血液中阿霉素的含量。结果 靶向组大白鼠的胃壁、肝脏组织及门静脉血液中阿霉素的浓度 ,明显高于非靶向组相应组织和血液中的药物浓度 ,且维持时间长 (P <0 .0 1)。结论 ADM MAMs联合外磁场的靶向给药方法可使靶区胃壁、肝脏组织及门静脉血液中的药物浓度长时间维持在较高水平 ,为临床预防及治疗胃癌肝转移提供了实验依据。
Objective To investigate the pharmacokinetics of target area tissues of adriamycin magnetic microspheres (ADM MAMs) after targeted drug delivery. Methods 10 0 Wastar rats were divided into group A (target group for digestive tract administration), group B (non-target group for digestive tract administration), group C (target group for tail vein administration), group D Tail vein administration of non-target group), each group of 24 animals, the fluorescence spectrophotometry detection and comparison of each group of rats stomach, liver tissue and portal vein doxorubicin content. Results The concentration of doxorubicin in the stomach, liver and portal vein of the target group rats was significantly higher than that of the corresponding tissues and blood of the non-target group and maintained for a long time (P <0.01). Conclusion The combination of ADM MAMs and external magnetic field can prolong the concentration of drug in the gastric wall, liver tissue and portal vein for a long time and provide an experimental basis for clinical prevention and treatment of liver metastasis of gastric cancer.