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[期刊论文] 作者：LU Jin-Jian,WANG Yi-Tao,
来源：中国天然药物 年份：2020
Natural products serve as abundant resources with diversity of chemical structures, which has been widely explored for the pharmacological researches and drug discovery [1, 2].They are generally isolated from microorganisms,plants, marine o......
PTEN bridges protective autophagy and apoptosis induced by DNA damage mediated by reactive oxygen sp
[期刊论文] 作者：NIU Ya-nan,SUN Wen,LU Jin-jian,
来源：中国药理学与毒理学杂志 年份：2016
OBJECTIVE Reactive oxygen species(ROS)mediated both apoptosis and protective autophagy in response to natural products while the detailed mechanisms remain uncl...
Towards a better understanding of the therapeutic potential of Rhizoma Alismatis: A phytochemical an
[会议论文] 作者：ZHANG Le-le,WANG Yi-tao,LU Jin-jian,,
来源：中国药理学与毒理学杂志 年份：2016
Rhizoma Alismatis(RA),the dried rhizome of Alisma orientalis(Sam.)Juzep,isa widely used traditional herbal medicine popularly known as″Ze Xie″in Chinese.RA is...
Towards a better understanding of the therapeutic potential of Rhizoma Alismatis: A phytochemical an
[会议论文] 作者：ZHANG Le-le,WANG Yi-tao,LU Jin-jian,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
Rhizoma Alismatis (RA), the dried rhizome of Alisma orientalis (Sam.) Juzep, isa widely used traditional herbal medicine popularly known as "Ze Xie" in Chinese.RA is an important crude herb component...
PTEN bridges protective autophagy and apoptosis induced by DNA damage mediated by reactive oxygen sp
[会议论文] 作者：NIU Ya-nan,SUN Wen,LU Jin-jian,CHEN Xiu-ping,,
来源：中国药理学与毒理学杂志 年份：2016
OBJECTIVE Reactive oxygen species(ROS)mediated both apoptosis and protective autophagy in response to natural products while the detailed mechanisms remain uncl...
PTEN bridges protective autophagy and apoptosis induced by DNA damage mediated by reactive oxygen sp
[会议论文] 作者：NIU Ya-nan,SUN Wen,LU Jin-jian,CHEN Xiu-ping,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE Reactive oxygen species (ROS) mediated both apoptosis and protective autophagy in response to natural products while the detailed mechanisms remain unclear.Cucurbitacin B (Cuc B), a natural...
Hypaconitine inhibits TGF-β1-induced epithelial–mesenchymal transition and suppresses adhesion,migra
[期刊论文] 作者：FENG Hai-Tao,ZHAO Wen-Wen,LU Jin-Jian,WANG Yi-Tao,CHEN Xiu-Ping,,
来源：Chinese Journal of Natural Medicines 年份：2017
Epithelial-mesenchymal transition(EMT) has been implicated in tumor invasion and metastasis and provides novel strategies for cancer therapy. Hypaconitine(HpA),...
Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion ki
[期刊论文] 作者：LUO Wei-Wei,ZHAO Wen-Wen,LU Jin-Jian,WANG Yi-Tao,CHEN Xiu-Ping,
来源：中国天然药物 年份：2018
Metastasis is responsible for the majority of cancer-related deaths and prevention of metastasis remains a big challenge for cancer therapy.Cucurbitacin B (Cuc B) is a natural triterpenoid with potent anticancer activities while its effect ......
Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses adhesion, migr
[期刊论文] 作者：FENG Hai-Tao,ZHAO Wen-Wen,LU Jin-Jian,WANG Yi-Tao,CHEN Xiu-Ping,
来源：中国天然药物 年份：2017
Epithelial-mesenchymal transition (EMT) has been implicated in tumor invasion and metastasis and provides novel strategies for cancer therapy.Hypaconitine (HpA),a diester-diterpenoid alkaloid isolated from the root of the Aconitum species,e......
[期刊论文] 作者：LU Jin-Jian,LU De-Zhao,CHEN Yu-Fei,DONG Ya-Ting,ZHANG Jun-Ren,LI Ting,TANG Zheng-Hai,
来源：中国天然药物 年份：2015
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[期刊论文] 作者：LU Jin-Jian,LU De-Zhao,CHEN Yu-Fei,DONG Ya-Ting,ZHANG Jun-Ren,LI Ting,TANG Zheng-Hai,YANG Zhen,,
来源：Chinese Journal of Natural Medicines 年份：2015
Platycodin D(PD), a triterpenoid saponin isolated from Platycodonis Radix, is a famous Chinese herbal medicine that has been shown to have anti-proliferative ef...
[会议论文] 作者：XU Xiao-huang,LI Ting,ZHANG Le-le,CHEN Xin,GUO Xia,CHEN Xiu-ping,WANG Yi-tao,LIN Li-gen,LU Jin-jian,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE Garcinone E, a xanthone derivative isolated from mangosteen, has been reported to have cytotoxic capacities.We aim to study the anticancer effects...
[期刊论文] 作者：XU Xiao-huang,LI Ting,ZHANG Le-le,CHEN Xin,GUO Xia,CHEN Xiu-ping,WANG Yi-tao,LIN Li-gen,LU Jin-jian,,
来源：中国药理学与毒理学杂志 年份：2016
OBJECTIVE Garcinone E,a xanthone derivative isolated from mangosteen,has been reported to have cytotoxic capacities.We aim to study the anticancer effects of ga...
[会议论文] 作者：XU Xiao-huang,ZHANG Le-le,WU Guo-sheng,CHEN Xin,LI Ting,LIU Jian-lin,CHEN Xiu-ping,WANG Yi-tao,LU Jin-jian,
来源：中国药理学会第十三次全国学术大会 年份：2015
Aim Solasodine, a steroidal alkaloid isolated from solanaceous species, has been reported to exhibit anticancer activity on several cell lines.The aim of this study is to explore the antitumor potenti...
[会议论文] 作者：XU Xiao-huang,LI Ting,ZHANG Le-le,CHEN Xin,GUO Xia,CHEN Xiu-ping,WANG Yi-tao,LIN Li-gen,LU Jin-jian,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE Garcinone E, a xanthone derivative isolated from mangosteen, has been reported to have cytotoxic capacities.We aim to study the anticancer effects of garcinone E on ovarian cancer cells....
Suppression of AOM/DSS-induced colorectal cancer by scutellarin through downregulation of Wnt signal
[期刊论文] 作者：ZENG Sha,ZHAO Hui,CHEN Li,SUN Qiang,REN Shan,LIU Mao-lun,YANG Han,TANG Shun,LU Jin-jian,XU Hai-bo,
来源：中国药理学与毒理学杂志 年份：2021
OBJECTIVE To investigate the therapeutic effect of scutellarin on colitis-associated cancer(CAC)and its underlying mechanism based on Wnt/β-catenin signaling pathway.METHODS The mouse model of CAC was established by azomethane oxide(AOM)an......
[期刊论文] 作者：LIU Mao-lun,SUN Qiang,ZENG Sha,CHEN Li,ZHAO Hui,YANG Han,REN Shan,MING Tian-qi,LU Jin-jian,XU Hai-bo,
来源：中国药理学与毒理学杂志 年份：2021
Pulsatilla chinensis is a widely used traditional Chinese herb,which contains 56 types of chemical constituents,mainly including triterpenoid saponins,organic acids,coumarins and lignans.The largest portion of the ingredients in Pulsatilla ......
[期刊论文] 作者：Yu-chi,HE Xin-ling,QI Lu,SHI Wei,YUAN Luo-wei,HUANG Mu-yang,XU Yu-lian,CHEN Xiu-ping,ZHANG Le-le,LU Jin-jian,
来源：中国药理学与毒理学杂志 年份：2021
OBJECTIVE Programmed death ligand-1(PD-L1)and indoleamine 2,3-dioxygenase 1(IDO1)are immune checkpoints which can be induced by interferon-γ(IFN-γ)in the tumor microenvironment,leading to immune escape of tumors.Myricetin(MY)is a flavonoi......
[期刊论文] 作者：REN Shan,SUN Qiang,CHEN Li,ZENG Sha,ZHAO Hui,LIU Mao-lun,YANG Han,MING Tian-qi,LU Jin-jian,XU Hai-bo,
来源：中国药理学与毒理学杂志 年份：2021
Oleanolic acid(OA)is a pentacyclic triterpenoid chemical component that exists in natural plants with a molecular formula of C30H48O3 and a molecular weight at 456.71 g·mol-1.OA is widespread in traditional Chinese herbal medicine(Ligustri......
Inhibitory action of berberine on colorectal cancer HCT116 cells by regulation of Hedgehog signaling
[期刊论文] 作者：SUN Qiang,CHEN Li,ZENG Sha,LIU Mao-lun,REN Shan,ZHAO Hui,YANG Han,MING Tian-qi,LU Jin-jian,XU Hai-bo,
来源：中国药理学与毒理学杂志 年份：2021
OBJECTIVE To investigate the inhibition and mechanism of berberine on human colorectal cancer HCT116 cells through canonical Hedgehog signaling pathway.METHODS The effect of berberine on cell morphology was observed by microscopy.MTT colori......
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