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Secalonic acid D reduced the percentage of side populations by down-regulating the expression of ABC
[会议论文] 作者：Ya-peng Hu,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
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[会议论文] 作者：Jing-hong Xu,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
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Effective targeting of cancer stem cell-like side population cells by tyrosine kinase inhibitor afat
[会议论文] 作者：Xiao-kun Wang,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
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Nilotinib enhanced the efficacy of conventional chemotherapeutic drugs in CD34+CD38-stem cells and A
[会议论文] 作者：Fang Wang,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
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Secalonic acid D reduced the percentage of side populations by down-regulating the expression of ABC
[会议论文] 作者：Ya-peng Hu,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
Background:The side population cells characterized by the ability to transport Hoechst 33342 out of cells have been identified as cancer stem-like cells.ABCG2 is found to confer the side population (S...
Nilotinib enhanced the efficacy of conventional chemotherapeutic drugs in CD34+CD38-stem cells and A
[会议论文] 作者：Fang Wang,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
Background:Incomplete chemotherapeutic eradication of leukemic CD34+38-stem cells is likely to result in disease relapse.The purpose of this study was to evaluate the effect of nilotinib on eradicatin...
Effective targeting of cancer stem cell-like side population cells by tyrosine kinase inhibitor afat
[会议论文] 作者：Xiao-kun Wang,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
Background Cancer stem cells (CSCs),which are considered as the tumor origin and are often resistant to chemotherapy and radiotherapy,are currently a major obstacle for treatment.One particularly intr...
Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10
[会议论文] 作者：Hui Zhang,Li-Wu Fu,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Objective: Linsitinib, a novel dual insulin-like growth factor 1 (IGF-1R)/insulin receptor (IR) kinase inhibitor in phase Ⅲ clinical trial, was investigated the reversal of multidrug resistance (MDR)...
[会议论文] 作者：Dong-juan Qiao,Xiao-kun Wang,Li-wu Fu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
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Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-li
[会议论文] 作者：Xiao-kun Wang,Fang Wang,Hui Zhang,Zhen-cong Huang,Li-wu Fu,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Cancer stem-like cells (CSC) have garnered significant attention as a therapeutic focus, based on evidence they may represent an etiologic root of treatment-resistant cells.Indeed, expression of the m...
[期刊论文] 作者：Qiu-Liang Wu,Xing-Ping Wu,Yong-Ju Liang,Li-Ming Chen,Yan Ding,Li-Wu Fu,
来源：世界胃肠病学杂志（英文版） 年份：2005
AIM: To verify whether P-glycoprotein (P-gp) could induce cell resistance to apoptosis by inhibiting caspase-8 and caspase-3.METHODS: Human KB cells, either dru...
,FG020326-1oaded nanoparticle with PEG and PDLLA improved pharma-codynamics of reversing multidrug r
[期刊论文] 作者：Wen-jing DENG,Xiao-qiang YANG,Yong-ju LIANG,Li-ming CHEN,Yan-yan YAN,Xin-tao SHUAI,Li-wu FU,
来源：中国药理学报（英文版） 年份：2007
Aim: FG020326, a novel imidazole derivative, is a potent multidrug-resistance (MDR) modulator in vitro and in vivo. However, FG020326 is insoluble. PEDLLA-FG020...
Lapatinib antagonizes multidrug resistance protein 1-mediated multidrug resistance by inhibiting its
[会议论文] 作者：Shaolin Ma,Ya-peng Hu,Fang Wang,Zhen-cong Huang,Yi-fan Chen,Xiao-kun Wang,Li-wu Fu,
来源：第八届中国肿瘤学术大会暨抗癌药物专业委员会中青年论坛 年份：2014
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Lapatinib antagonizes multidrug resistance protein 1-mediated multidrug resistance by inhibiting its
[会议论文] 作者：Shaolin Ma,Ya-peng Hu,Fang Wang,Zhen-cong Huang,Yi-fan Chen,Xiao-kun Wang,Li-wu Fu,
来源：第八届中国肿瘤学术大会暨抗癌药物专业委员会中青年论坛 年份：2014
Objective: Lapatinib, which is used in the treatment with advanced or metastatic breast cancer overexpressing human epidermal receptor 2 (HER2), is an inhibitor of the tyrosine kinase EGFR (ErbB1) and...
Lapatinib antagonizes multidrug resistance-associated protein 1 mediated multidrug resistance by inh
[会议论文] 作者：Shao-lin Ma,Ya-peng Hu,Fang Wang,Zhen-cong Huang,Yi-fan Chen,Xiao-kun Wang,Li-wu Fu,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Lapatinib, a tyrosine kinase inhibitor (TKI), is used in the treatment of advanced or metastatic breast cancer overexpressing human epidermal receptor 2 (HER2).Lapatinib can modulate the function of A...
Neratinib (HKI-272) Reverses ABCB 1-Mediated Chemotherapeutic Drug Resistance in Vitro,in Vivo and e
[会议论文] 作者：Xiao-qin Zhao,Suresh V.Ambudkar,Zhe-Sheng Chen,Li-wu Fu,Jing-dun Xie,Xing-gui Chen,Hong May Sim,Xu Zhang,
来源：2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2012
Neratinib (HIK-272),an irreversible inhibitor of EGFR and Her-2,is in phase Ⅲ clinical trials for patients with Her-2-positive locally advanced or metastatic breast cancer.The objective of this study...
[会议论文] 作者：,Hong-Bo Wang,Yong Du,Mei-Ling Chen,Ao Zhang,Zhi-Xin Fang,Jiang-Yi He,Li Yuan,Qian Zhong,Bo Zhao,Li-Wu Fu,
来源：病毒感染与免疫应答国际研讨会(Nature Conference:Viral Infection and Immune 年份：2016
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β-catenin/p300 signaling activation by CBP blockade induces cell senescence in wild-type or T315I-mu
[会议论文] 作者：Su,Xingping WU,Qian-Qian Han,Zhen Chen,Zhi Shi,Kenneth Kin Wah To,Brian J.Druker,Zhe-Sheng Chen,Li-Wu Fu,
来源：2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2016
Chronic myeloid leukemia(CML)is a clonal malignant disorder of pluripotent hematopoietic stem cells(HSCs)characterized by the formation of the novel breakpoint cluster region-Abelson tyrosine kinase(B...
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