PLUMBAGIN相关论文
Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug de
Metal-organic frameworks (MOFs) have recently allured a variety of concern in the fields of nanotech-nology.However,expl......
Despite the significant advantages of nano-micellar systems on drug delivery,the poor therapeutic outcome in clinic is a......
Aim: To investigate the combinatorial anti-tumorigenesis and anti-osteoclastogenesis effects of plumbagin and zoledronic......
ObjectToexploretheeffectofPlumbaginonthegrowthofosteosarcomacelllineMG-63andits possibleunderlyingmechnisms.......
Plumbagin protects liver against thioacetamide-induced fulminant hepatic failure and chronic liver f
Aims: In this study, we investigated the effect of Plumbagin on liver protection in acute and chronic damage induced by ......
Background: Plumbagin (PL, 5-hydroxy-2-methyl-1,4-naphthoquinone) is an herbal compound derived from medicinal plants of......
Plumbagin Ameliorates CCl4-induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor
Objective Epidermal growth factor(EGF)and its signaling molecules — EGFreceptor(EGFR)and signal transducer and activato......
Inhibitory effect of plumbagin, a potential anticancer natural compound, on cytochrome P450 2J2 in h
OBJECTIVE Cytochrome P450 (CYP) 2J2 is highly expressed in many kinds of human tumors and promotes tumor cell growth via......
Aim: Medicinal plant extracts are alternative sources of promising anti-cancer compound such as Plumbago extracts.Theref......
由于新药研发耗资大、周期长、风险高,越来越多的学者把目光投向天然产物的研究. 中药成分蓝雪醌是一种天然的α-萘醌类化合物,主......
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Inhibitory activities of plumbagin on cell migration and invasion and inducing activity on cholangio
Objective: To investigate the cytotoxic, apoptotic and inhibitory activities on cell migration and invasion of plumbagin......
Plumbagin Enhances TRAIL-mediated Apoptosis through Up-regulation of Death Receptor in Human Melanom
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anti-cancer agent.However,emergence of dr......
目的:比较广西不同产地瑶药猛老虎中的白花丹醌的含量,为猛老虎药材的合理开发利用提供依据。方法:采用HPLC法,采用ZORBAX Eclipse......
,Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro thr
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,Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mi
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,Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic aci
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,Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 exp
Chronic periodontitis (CP) is one of the most common oral diseases,which causes alveolar bone absorption and tooth loss ......
目的探讨白花丹素对舌鳞状细胞癌（tongue squamous cell carcinoma，TSCC）细胞上皮间质转化的作用及其可能机制，为白花丹素治疗TSCC提供......
目的研究天然小分子复合物白花丹素对人类非小细胞癌H23细胞的凋亡作用及其内在机制。方法应用不同浓度梯度的白花丹素(0.5~200μm......
Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition
Objective:The aim of this study was to investigate the effects of plumbagin(PL),a naphthoquinone derived from the medici......
目的研究白花丹醌经Caco-2细胞及大鼠肠道的转运特征。方法应用Caco-2细胞模型和翻转肠囊法考察转运时间、药物浓度对白花丹醌吸收......
Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition
Objective:The aim of this study was to investigate the effects of plumbagin (PL), a naphthoquinone derived from the medi......
目的 探讨白花丹素对前列腺癌PC-3细胞增殖、凋亡的作用及其和RelA(p65)表达的关系.方法 应用不同浓度梯度的白花丹素(1、5、1O、1......
目的 分析中药提纯制剂白花丹素对胶质瘤细胞增殖、凋亡和侵袭能力的影响及其作用机制. 方法 体外常规培养SWO-38和U251细胞,应用0......
用圆二色和拉曼光谱法表征了Cu2+或Mn2+存在下白花丹素对人血清白蛋白构象的影响.结果表明,白花丹素改变了人血清白蛋白的二级结构......
目的探讨白花丹素(Plumbagin,PL)对LPS诱导的巨噬细胞产生细胞因子的影响。方法实验设置白花丹素低剂量组、白花丹素中剂量组、白......
目的:探讨白花丹醌是否诱导人结肠腺癌Caco-2细胞凋亡和自噬及其对磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(PKB/Akt)/哺乳动物雷帕霉素......
目的建立反相高效液相色谱法（RP-HPLC）法测定通迪胶囊中白花丹醌的含量。方法用Chrom atorax C18色谱柱（ODS4.6 mm×250 mm,5μm）,......
[目的]比较白花丹新鲜叶及干燥叶中白花丹醌含量的高低。[方法]采用水蒸气蒸馏法提取白花丹叶中的白花丹醌,用高效液相色谱仪检测......
目的分析不同产地白花丹药材中白花丹醌含量的差异。方法采用KromasilC18柱（4.6mm×200mm,5μm）,柱温：30℃,流动相：甲醇-水（65∶35）,......
目的：评价白花丹素对黑素瘤细胞体外增殖及凋亡的影响。方法：体外培养黑素瘤细胞A375细胞株，应用不同浓度的白花丹素进行处理，培养24h......
目的研究白花丹素（PL）对结核分枝杆菌的基因表达谱的影响。方法微量稀释法确定PL对结核分枝杆菌H37RV的MIC,1/2×MIC作用4 h后收......
目的： 探讨白花丹素（PB）联合术前诱导化疗PF方案对舌癌细胞Tca-8113的化疗增敏作用及其相关机制。方法： 体外培养舌癌细胞株Tca-8113，设......
[目的]检测白花丹花和果实中白花丹醌的含量,为白花丹花和果实的临床应用及开发提供依据。[方法]采用无水甲醇（50 ml）冷浸药材粉末24......
采用水蒸气蒸馏法提取白花丹茎中的醌类化合物，并测定化合物中白花丹醌的含量。结果表明，白花丹鲜茎与干燥茎中白花丹醌的含量分别为......
目的：观察白花丹素在体外对人胚肾细胞293的毒性,以及酸性成纤维细胞生长因子（aFGF）对白花丹素所致肾损伤的保护作用。方法：采用四噻唑......
白花丹素（Plumbagin，简称PLN）是从传统中药白花丹中提取出来的具有抗肿瘤活性的萘醌类化合物（2-甲基-5-羟基-1，4萘醌），而白花丹素镧（Ⅲ）配合......
以从传统中药白花丹中提取出来的白花丹素为配体,合成白花丹素钇（Ⅲ）的配合物[Y（PLN）_3（H_2O）_2],通过MTT法研究其对细胞株BEL7404的抗肿......
【摘要】 目的：研究白桦丹醌在抗人类肺腺癌细胞系PC9骨转移中的作用。 方法：采用左心室注射稳转荧光素酶的PC9细胞构建肺癌骨转移动......
目的 研究白花丹醌对脂多糖（LPS）诱导的体外培养CIA大鼠成纤维样滑膜细胞（CIA-FLS）的增殖及肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）......
对从植物中提取的矶松素的大π电子体系进行ＨＭＯ计算。计算表明：矶松素可能具有较大的二创极化率和可能存在双稳态结构，是分子器件和非线......
目的 对多民族药材白花丹（Phurabago reylanica L．）中的白花丹醌进行提取分离和鉴定。方法 用硅胶柱层析分离；用TLC，IR，MS，NMR等技术鉴定......
根据作者已往的临床经验，中草药白花丹对急性早幼粒细胞白血病（APL）治疗有效，但至今尚无关于白花丹对APL疗效方面的系统研究。本研究的......
Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition
Objective:The aim of this study was to investigate the effects of plumbagin(PL),a naphthoquinone derived from the medici......
目的:探讨白花丹素联合X-射线对舌癌细胞Tca-8113的放疗增敏作用及其机制。方法:体外培养舌癌细胞株Tca-8113,分空白对照组、单纯......
用圆二色和拉曼光谱法表征了Cu^2＋或Mn^2＋存在下白花丹素对人血清白蛋白构象的影响。结果表明，白花丹素改变了人血清白蛋白的二级结构......
目的观察白花丹醌对白血病异种移植瘤的体内作用。方法用NB4细胞构建白血病小鼠模型,白花丹醌组（2mg/（kg.d））,亚砷酸组（4mg/（kg.d））,分别腹......
