PRESENILIN-1相关论文
γ-secretase is a multimeric intramembrane protease which responsible for the cleavage of various type-Ⅰ transmembrane ......
目的探讨早发型阿尔茨海默病(EOAD)先证者及其家系的临床与遗传学特点和致病基因突变特征。方法对3例EOAD先证者及其家庭成员进行......
,Down-regulation amyloid β-protein 42 production by interfering with transcript of presenilin 1 gene
AIM: To investigate the pathogenesis of Aβ42 yielding and new drug targets as well as the possibility of RNA interferen......
,Effects of presenilins and β-amyloid precursor protein on delayed rectifier potassium channels in c
AIM: To study the effects of presenilin-1 (PS-1), presenilin-2 (PS-2), and amyloid beta-protein precursor (APP695)on del......
Mutant amyloid precursor protein and presenilin-1 genes effect on ischemia vulnerability via calcium
BACKGROUND: Previous studies have demonstrated that mutant amyloid precursor protein (APP) or presenilin-1 (PS1) genes i......
Mutant amyloid precursor protein and presenilin-1 genes effect on ischemia vulnerability via calcium
BACKGROUND: Previous studies have demonstrated that mutant amyloid precursor protein (APP) or presenilin-1 (PS1) genes i......
目的 观察PS-1突变型L286V对RA诱导的PC12细胞生长和凋亡的影响.方法运用脂质体介导的基因转染技术建立稳定表达PS-1 WT和突变型L2......
期刊
Mice carrying mutant amyloid-β precursor protein and presenilin-1 genes (APP/PS1 double trans-genic mice) have frequent......
目的 探讨突变型早老素-1(PS-1)对维甲酸(RA)诱导PC12细胞基因表达的影响,寻找与阿尔茨海默病发病机制相关的基因.方法 分别建立表......
目的使用前脑特异性敲除早老素-1(PS-1FB-KO)的小鼠模型,观察饮食对其体重的影响以及表没食子儿茶素没食子酸酯(EGCG)对该小鼠体重......
[摘要]目的探讨早老素-1（PSEN-1）p.Met139Ile突变对早发性阿尔茨海默病（EOAD）人神经母细胞瘤细胞（SH-SY5Y细胞）模型中相关蛋白及microRNA......
目的研究早老素-1基因启动子区-48C/T位点的多态性与迟发性AD(LOAD)的相关性.方法用常规方法从人外周血白细胞中抽提基因组DNA,PCR......
目的探讨人参皂甙Rb1对AD大鼠顶叶皮质β-分泌酶及PS-1表达的影响。方法30只健康雄性SD大鼠，随机分为对照组、模型组和治疗组。模型......
目的 观察多奈哌齐对慢性脑灌注不足(CVI)大鼠脑早老素-1(PS-1)蛋白水平的影响.方法 90只雄性Wistar大鼠随机分为假手术对照组、单......
目的 观察降血脂药普伐他汀对慢性脑缺血(CVI)大鼠脑海马区早老素-1(PS-1)蛋白水平的影响.方法 36只雄性Wistar大鼠随机分为正常对......
目的 探讨阿尔茨海默病（AD）早老素-1（PS-1）基因第3外显子的突变特点。方法 采用聚合酶链反应及基因测序技术，对12例血管性痴呆（VD）患者、1......
目的观察早老蛋白-1（Presenilin-1，PS1）的过度表达对tau蛋白磷酸化的影响。方法在NC-108细胞上转染不同的PS1质粒，利用免疫双标，免疫印......
早老素-1(PS-1)基因的发现是继APP基因之后在阿尔茨海默病(AD)分子生物学研究领域取得的巨大进展,本文就PS-1基因的分子结构、PS-1......
